Anticancer activity of novel 3-azaxanthenes was written by Kibardina, Lyudmila K.;Trifonov, Alexey V.;Dobrynin, Alexey B.;Pudovik, Michail A.;Burilov, Alexander R.;Voloshina, Alexandra D.;Strelnik, Anna G.;Gazizov, Almir S.. And the article was included in Mendeleev Communications in 2021.SDS of cas: 65-22-5 The following contents are mentioned in the article:
Novel 3-azaxanthenes have been synthesized via acid-catalyzed one-pot Friedel-Crafts reaction of pyridoxal/pyridoxal-5-phosphate with naphthols followed by dehydration of the intermediate bis(2-hydroxyaryl)-(pyridin-4-yl)methane derivatives The cytotoxicity of the obtained 3-azaxanthenes against M-HeLa and HuTu-80 tumor cell lines is comparable to that of tamoxifen, whereas the cytotoxicity against normal cell line is absent in the tested concentratons range, which makes this class of compounds interesting for further studies. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5SDS of cas: 65-22-5).
3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 65-22-5
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts