Preston, Alex published the artcileGSK973 Is an Inhibitor of the Second Bromodomains (BD2s) of the Bromodomain and Extra-Terminal (BET) Family, Synthetic Route of 6346-09-4, the publication is ACS Medicinal Chemistry Letters (2020), 11(8), 1581-1587, database is CAplus and MEDLINE.
Pan-BET inhibitors have shown profound efficacy in a number of in vivo preclin. models and have entered the clinic in oncol. trials where adverse events have been reported. These inhibitors interact equipotently with the eight bromodomains of the BET family of proteins. To better understand the contribution of each domain to their efficacy and to improve from their safety profile, selective inhibitors are required. This Letter discloses the profile of GSK973, a highly selective inhibitor of the second bromodomains of the BET proteins that has undergone extensive preclin. in vitro and in vivo characterization.
ACS Medicinal Chemistry Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Synthetic Route of 6346-09-4.
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