October, Jacquin; Mapolie, Selwyn F. published their research in Tetrahedron Letters in 2021. The article was titled 《Sequential hydroaminomethylation/Pd-catalyzed hydrogenolysis as an atom efficient route to valuable primary and secondary amines》.Application of 4048-33-3 The article contains the following contents:
The facile synthesis of valuable primary and secondary amines RRNH (R = nonyl, 2-cyclohexylethyl, 4-(4-methoxyphenyl)butyl, etc.) and RNH2 is reported using a sequential procedure of hydroaminomethylation and Pd-catalyzed hydrogenolysis. The hydroaminomethylation reaction was catalyzed by a cationic Rh(I) iminopyridyl complex and the N-alkylated benzylamines RRNBn and RNHBn were produced with high chemoselectivity, albeit as mixtures of linear and branched products. Performing the hydrogenolysis reaction using 10% Pd/C, provided access to valuable primary and secondary amines which have applications in the surfactant, pharmaceutical and polymer industries. In addition to this study using 6-Aminohexan-1-ol, there are many other studies that have used 6-Aminohexan-1-ol(cas: 4048-33-3Application of 4048-33-3) was used in this study.
6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Application of 4048-33-3
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