《In-situ layer-by-layer synthesized TpPa-1 COF solid-phase microextraction fiber for detecting sex hormones in serum》 was written by Zheng, Jiating; Huang, Shuyao; Tong, Yuanjun; Wei, Songbo; Chen, Guosheng; Huang, Siming; Ouyang, Gangfeng. Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehydeThis research focused onTpPa1 COF solid phase microextraction fiber serum sex hormone; testosterone progesterone dehydroepiandrosterone TpPa1 COF; In-situ layer-by-layer synthesis; Sex hormone detection; Solid-phase microextraction; TpPa-1 COFs. The article conveys some information:
The secretion disorder of sex hormones is the source that leads to the occurrence of many diseases such as polycystic ovarian syndrome (PCOS), hyperandrogenism and so on. There exist physiol. changes in human body when slight fluctuations in concentrations of sex hormones happen. Therefore, it′s of great significance for accurate detection of sex hormones in human body. In this work, TpPa-1 COF solid-phase microextraction (SPME) fiber was prepared using high-efficient in-situ synthesis strategy and coupled with HPLC-MS/MS to detect three sex hormones, including Progesterone (P), testosterone (T) and dehydroepiandrosterone (DHEA) in human serum. The thickness of the coating reached 7 μm within 2 h. Under the optimal conditions, the established method presented low limit of detections (LODs, ≤ 0.75 ng/mL), wide linear ranges (0.100-100 ng mL-1) and good reproducibility, and three sex hormones (T, P, DHEA) were successfully detected and quantified in human serum. In conclusion, the established SPME method presented high-efficient fiber preparation and good anal. performances of sex hormone detection, therefore was in great potential for application in clin.2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde) was used in this study.
2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Reference of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde
Referemce:
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Alcohols – Chemistry LibreTexts