The author of 《Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives》 were Gokmen, Zeliha; Onan, Mehmet Erdi; Deniz, Nahide Gulsah; Karakas, Didem; Ulukaya, Engin. And the article was published in Synthetic Communications in 2019. Electric Literature of C6H15NO The author mentioned the following in the article:
New N- and S,S-substituted-1,4-naphthoquinone (1,4 NQ) derivatives such as I [R = 2-furoyl, 4-FC6H4CH2, 2-pyridinyl, etc.] and II resp. were synthesized in excellent yields and were completely characterized by spectroscopic anal. IR, NMR (1H and 13C), MS and microanal. The cytotoxic activities of 1,4-NQ derivatives I and II were examined against A-549, DU145, HCT-116 and MDA-MB-231 cancer cells. Among these compounds, I [R = 2-furoyl] and II were identified as the most potent anticancer agents with cytotoxic activity against three cell lines (breast (MDA-MB-231), prostate (DU145), colorectal (HCT-116)). The experimental part of the paper was very detailed, including the reaction process of 6-Aminohexan-1-ol(cas: 4048-33-3Electric Literature of C6H15NO)
6-Aminohexan-1-ol(cas: 4048-33-3) can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine. It may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties.Electric Literature of C6H15NO
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