On May 31, 2021, van den Berg, Fons F.; van Dalen, Demi; Hyoju, Sanjiv K.; van Santvoort, Hjalmar C.; Besselink, Marc G.; Wiersinga, Willem Joost; Zaborina, Olga; Boermeester, Marja A.; Alverdy, John published an article.Category: alcohols-buliding-blocks The title of the article was Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate. And the article contained the following:
The gut microbiota are the main source of infections in necrotising pancreatitis. We investigated the effect of disruption of the intestinal microbiota by a Western-type diet on mortality and bacterial dissemination in necrotising pancreatitis and its reversal by butyrate supplementation. C57BL/6 mice were fed either standard chow or a Western-type diet for 4 wk and were then subjected to taurocholate-induced necrotising pancreatitis. Blood and pancreas were collected for bacteriol. and immune anal. The cecum microbiota composition of mice was analyzed using 16S rRNA gene amplicon sequencing and cecal content metabolites were analyzed by targeted (ie, butyrate) and untargeted metabolomics. Prevention of necrotising pancreatitis in this model was compared between faecal microbiota transplantation (FMT) from healthy mice, antibiotic decontamination against Gram-neg. bacteria and oral or systemic butyrate administration. Addnl., the faecal microbiota of patients with pancreatitis and healthy subjects were analyzed. Mortality, systemic inflammation and bacterial dissemination were increased in mice fed Western diet and their gut microbiota were characterised by a loss of diversity, a bloom of Escherichia coli and an altered metabolic profile with butyrate depletion. While antibiotic decontamination decreased mortality, Gram-pos. dissemination was increased. Both oral and systemic butyrate supplementation decreased mortality, bacterial dissemination, and reversed the microbiota alterations. Paradoxically, mortality and bacterial dissemination were increased with FMT administration. Finally, patients with acute pancreatitis demonstrated an increase in Proteobacteria and a decrease of butyrate producers compared with healthy subjects. Butyrate depletion and its repletion appear to play a central role in disease progression towards necrotising pancreatitis. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Category: alcohols-buliding-blocks
The Article related to necrotising pancreatitis mortality microbiota butyrate, acute pancreatitis, antibiotics, bacterial infection, butyrate, diet, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks
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