On May 13, 2022, Shang, Rui; Liu, Can published a patent.Related Products of 386704-04-7 The title of the patent was Application method of thiophenol photocatalyst in defluorination alkylation or defluorination protonation reaction. And the patent contained the following:
The title method includes (1) mixing a trifluoromethyl compound (with a formula I as shown in Claim 2, such as trifluoromethyl (hetero)alkyl compounds, trifluoroacetamide compounds, etc.) and/or polyfluoroalkyl compound (with a formula II, such as pentafluoroacetamide compounds, etc.), thiophenol photocatalyst (4-methoxythiophenol, 4-methylthiophenol, etc.), formate salt (sodium formate, calcium formate, etc.) and organic solvent (DMF, THF, etc.) to form a reaction mixture. (2) Irradiating under the protection of inert gas for a defluorination reaction to obtain a difluoromethyl free radical and/or polyfluoroalkyl free radical intermediate product. (3) Reacting with unsaturated olefin (with formula III as shown in Claim 5, such as dimethyl(phenyl)(vinyl)silane, but-3-en-1-ol, etc.) to obtain a defluorination alkylation product (6-(3-(dimethyl(phenyl)silyl)-1,1-difluoropropyl)pyridin-2-amine, 5-(6-aminopyridin-2-yl)-5,5-difluoropentan-1-ol, etc.). (4) Or reacting the intermediate product as hydrogen donor with formate salt to obtain a defluorination protonation product. In formulas I-III, R is amido, ester group, aryl or heteroaryl; and R’ is or cycloalkyl. The thiophenol photocatalyst has the advantages of low cost and environment friendliness. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Related Products of 386704-04-7
The Article related to thiophenol photocatalyst alkylsilane preparation defluorination alkylation, Organometallic and Organometalloidal Compounds: Silicon Compounds and other aspects.Related Products of 386704-04-7
Referemce:
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Alcohols – Chemistry LibreTexts