On October 19, 2010, Yu, Guixue; Ewing, William R.; Mikkilineni, Amarendra B.; Pendri, Annapurna; Ellsworth, Bruce A.; Sher, Philip M.; Gerritz, Samuel; Sun, Chongqing; Murugesan, Natesan; Wu, Ximao published a patent.Application of 386704-04-7 The title of the patent was Preparation of azabicyclic heterocycles as cannabinoid receptor modulators. And the patent contained the following:
The present application describes compounds I [R1, R2 = halo, CN, alkyl, etc.; R3 = H alkyl, alkenyl, cycloalkyl, etc.; R4 is absent when n is a double bond; R4 = H, alkyl, cycloalkyl, etc.; R5 = halo, (un)substituted OH, NH2, etc. when m is a single bond; R5 = O when m = a double bond; m, n = a single or double bond; when m is a single bond, n is a double bond; when m is a double bond, n is a single bond], pharmaceutical compositions comprising at least one compound I and optionally one or more addnl. therapeutic agents and methods of treatment using the compounds I both alone and in combination with one or more addnl. therapeutic agents. Over 40 compounds I were prepared E.g., a multi-step synthesis of II, starting from dichloromandelic anhydride and hydrazine dihydrochloride, was given. The exemplified compounds I showed the CB-1 receptor binding Ki values in the range of 0.01 nM to 10000 nM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7
The Article related to azabicyclic heterocycle triazolopyridazine preparation cannabinoid receptor cb1 modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Application of 386704-04-7
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