Terashima, Kyu; Kawasaki-Takasuka, Tomoko; Yamazaki, Takashi published an article in 2021, the title of the article was Construction of fully substituted carbon centers containing a heteroatom and a CF3 group via in situ generated p-quinone methides.Formula: C10H22S And the article contains the following content:
1,6-Conjugate additions of δ-CF3-δ-substituted p-quinone methides, generated in-situ from silyl ethers I (R1 = Me, n-Pr, i-Pr, Ph, PhCC), have been achieved with a variety of heteronucleophiles under mild conditions, which led to facile and practical construction of the compounds II (X = PhCH2NH, PhNHNH, 1-pyrrolidinyl, 1-imidazolyl, F3CCH2O, PhO, i-PrS, PhS, etc.; R2 = H or TBS) with fully substituted carbon centers including a heteroatom and a CF3 group. In particular, it was revealed that some amines themselves worked for efficient cleavage of the TBS protective group, and addition of a catalytic amount of an appropriate Bronsted acid was found to sometimes improve the progress of the desired process. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Formula: C10H22S
The Article related to phenol trifluoromethyl aminoalkyl thioalkyl preparation, quinone methide generation conjugate addition amine thiol alc, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Phenols, Thiophenols, and Derivatives Including Phenol and Thiophenol Ethers and Esters and other aspects.Formula: C10H22S
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