On June 30, 2021, Smith, Chad; Trageser, Kyle J.; Wu, Henry; Herman, Francis J.; Iqbal, Umar Haris; Sebastian-Valverde, Maria; Frolinger, Tal; Zeng, Emma; Pasinetti, Giulio Maria published an article.Recommanded Product: 621-37-4 The title of the article was Anxiolytic effects of NLRP3 inflammasome inhibition in a model of chronic sleep deprivation. And the article contained the following:
Sleep deprivation is a form of stress that provokes both inflammatory responses and neuropsychiatric disorders. Because persistent inflammation is implicated as a physiol. process in anxiety disorders, we investigated the contributions of NLRP3 inflammasome signaling to anxiety and anxiolytic properties of flavanol diets in a model of chronic sleep deprivation. The results show a flavanol-rich dietary preparation (FDP) exhibits anxiolytic properties by attenuating markers of neuroimmune activation, which included IL-1β upregulation, NLRP3 signaling, and microglia activation in the cortex and hippocampus of sleep-deprived mice. Production of IL-1β and NLRP3 were critical for both anxiety phenotypes and microglia activation. Individual FDP metabolites potently inhibited IL-1β production from microglia following stimulation with NLRP3-specific agonists, supporting anxiolytic properties of FDP observed in models of sleep deprivation involve inhibition of the NLRP3 inflammasome. The study further showed sleep deprivation alters the expression of the circadian gene Bmal1, which critically regulated NLRP3 expression and IL-1β production The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Recommanded Product: 621-37-4
The Article related to sleep deprivation nlrp3 inflammasome anxiolytic, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Recommanded Product: 621-37-4
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