On July 2, 2020, Okuda, Yasuhiro; Imafuku, Kazuto; Tsuchida, Yoshiyuki; Seo, Tomoyo; Akashi, Haruo; Orita, Akihiro published an article.COA of Formula: C10H22S The title of the article was Process-Controlled Regiodivergent Copper-Catalyzed Azide-Alkyne Cycloadditions: Tailor-made Syntheses of 4- and 5-Bromotriazoles from Bromo(phosphoryl)ethyne. And the article contained the following:
We developed a regiodivergent syntheses of 4- and 5-bromo-substituted 1,2,3-triazoles in copper-catalyzed azide-alkyne cycloadditions (CuAACs) by taking advantage of bromo(phosphoryl)ethyne as a bromoethyne equivalent A one-shot dephosphorylative CuAAC afforded 4-bromotriazoles, which was transformed into a histone deacetylase 8 (HDAC8)-selective inhibitor, NCC-149. However, the direct CuAAC catalyzed by CuI/Cu(OAc)2 provided 5-bromo-4-phosphoryltriazoles. The consecutive nucleophilic substitution of the bromo group with thiols followed by MeOK-promoted dephosphorylation gave 5-thio-substituted triazoles. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).COA of Formula: C10H22S
The Article related to bromotriazole regiodivergent preparation copper catalyzed click cycloaddition bromophosphorylethyne, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.COA of Formula: C10H22S
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