On January 28, 2021, Kuttruff, Christian Andreas; Godbout, Cedrickx; Koolman, Hannes Fiepko; Roth, Gerald Juergen published a patent.Application In Synthesis of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was N-Methyl-N-(6-(methoxy)pyridazin-3-yl)amine derivatives as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases and preparation thereof. And the patent contained the following:
The invention relates to N-methyl-N-(6-(methoxy)pyridazin-3-yl)amine derivatives of formula I as autotaxin (ATX) modulators for the treatment of inflammatory airway or fibrotic diseases such as e.g. idiopathic lung disease (IFF) or systemic sclerosis (SSc). Compounds of formula I wherein A is substituted pyridyl; E is (un)substituted Ph and (un)substituted pyridyl; K is substituted piperazinyl, substituted piperidinyl and substituted pyrrolidinyl; L and M are independently H, Me and CH2OH; LM can be taken together to form cyclopropyl; are claimed. 1-[4-(4-{1-[(6-{[6-(Trifluoromethyl)pyridin-3-yl]methoxy}pyridazin-3-yl)amino]cyclopropyl}-phenyl)piperazin-l-yl]ethan-1-one (II) was prepared by N-arylation of 1-{4-[4-(1-aminocyclopropyl)phenyl]-piperazin-1-yl}ethan-1-one with 3-iodo-6-((6-(trifluoromethyl)pyridin-3-yl)methoxy)pyridazine. The invention compounds were evaluated for their ATX modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 2.5 nM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application In Synthesis of (6-(Trifluoromethyl)pyridin-3-yl)methanol
The Article related to pyridazinamine preparation autotaxin modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Application In Synthesis of (6-(Trifluoromethyl)pyridin-3-yl)methanol
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