Grabska-Kobylecka, Izabela; Kaczmarek-Bak, Justyna; Figlus, Malgorzata; Prymont-Przyminska, Anna; Zwolinska, Anna; Sarniak, Agata; Wlodarczyk, Anna; Glabinski, Andrzej; Nowak, Dariusz published an article in 2020, the title of the article was The presence of caffeic acid in cerebrospinal fluid: evidence that dietary polyphenols can cross the blood-brain barrier in humans.Synthetic Route of 621-37-4 And the article contains the following content:
Epidemiol. data indicate that a diet rich in plant polyphenols has a pos. effect on brain functions, improving memory and cognition in humans. Direct activity of ingested phenolics on brain neurons may be one of plausible mechanisms explaining these data. This also suggests that some phenolics can cross the blood-brain barrier and be present in the brain or cerebrospinal fluid. We measured 12 phenolics (a combination of the solid-phase extraction technique with high-performance liquid chromatog.) in cerebrospinal fluid and matched plasma samples from 28 patients undergoing diagnostic lumbar puncture due to neurol. disorders. Homovanillic acid, 3-hydroxyphenyl acetic acid and caffeic acid were detectable in cerebrospinal fluid reaching concentrations (median; interquartile range) 0.18; 0.14μmol/L, 4.35; 7.36μmol/L and 0.02; 0.01μmol/L, resp. Plasma concentrations of caffeic acid (0.03; 0.01μmol/L) did not correlate with those in cerebrospinal fluid (ρ = -0.109, p = 0.58). Because food (fruits and vegetables) is the only source of caffeic acid in human body fluids, our results indicate that the same dietary phenolics can cross blood-brain barrier in humans, and that transportation of caffeic acid through this barrier is not the result of simple or facilitated diffusion. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Synthetic Route of 621-37-4
The Article related to caffeic acid dietary polyphenol blood brain barrier cerebrospinal fluid, blood-brain barrier, caffeic acid, cerebrospinal fluid, dietary polyphenols, plant phenolics, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Synthetic Route of 621-37-4
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