On January 19, 2012, Brown, Alan Daniel; Rawson, David James; Storer, Robert Ian; Swain, Nigel Alan published a patent.Recommanded Product: 386704-04-7 The title of the patent was Preparation of sulfonamide derivatives as Nav1.7 inhibitors. And the patent contained the following:
The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors I [X = OCH2, CH2O; Het1 = (un)substituted 9-10 membered heteroaryl comprising 1-3 N atoms; R1 = (cyclo)alkyl (optionally substituted by 1-3 F atoms); R2-R4 = H, F, Cl or OMe; R5 = H, CN, F, Cl, etc.] which are potentially useful in the treatment of a wide range of disorders, particularly pain. Over sixty sulfonamides were prepared Thus, reacting 4-[(5-chloro-6-isobutoxypyridin-3-yloxy)methyl]-2,5-difluorobenzoic acid (preparation given) with methanesulfonamide afforded the sulfonamide II.HNEt2. Exemplified sulfonamides were tested for their ability to block the Nav1.7 channel (EIC50 values were provided). Pharmaceutical compositions comprising the title sulfonamide, alone or in combination with other therapeutic agent, were disclosed. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Recommanded Product: 386704-04-7
The Article related to sulfonamide benzamide preparation voltage gated sodium channel nav17 inhibitor, combination chemotherapy nav17 inhibitor sulfonamide amide benzamide preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Recommanded Product: 386704-04-7
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