Schjoedt, Mette S.; Gurdeniz, Gozde; Chawes, Bo published an article in 2020, the title of the article was The metabolomics of childhood atopic diseases: a comprehensive pathway-specific review.Synthetic Route of 621-37-4 And the article contains the following content:
A review. Asthma, allergic rhinitis, food allergy, and atopic dermatitis are common childhood diseases with several different underlying mechanisms, i.e., endotypes of disease. Metabolomics has the potential to identify disease endotypes, which could beneficially promote personalized prevention and treatment. Here, we summarize the findings from metabolomics studies of children with atopic diseases focusing on tyrosine and tryptophan metabolism, lipids (particularly, sphingolipids), polyunsaturated fatty acids, microbially derived metabolites (particularly, short-chain fatty acids), and bile acids. We included 25 studies: 23 examined asthma or wheezing, five examined allergy endpoints, and two focused on atopic dermatitis. Of the 25 studies, 20 reported findings in the pathways of interest with findings for asthma in all pathways and for allergy and atopic dermatitis in most pathways except tyrosine metabolism and short-chain fatty acids, resp. Particularly, tyrosine, 3-hydroxyphenylacetic acid, N-acetyltyrosine, tryptophan, indolelactic acid, 5-hydroxyindoleacetic acid, p-Cresol sulfate, taurocholic acid, taurochenodeoxycholic acid, glycohyocholic acid, glycocholic acid, and docosapentaenoate n-6 were identified in at least two studies. This pathway-specific review provides a comprehensive overview of the existing evidence from metabolomics studies of childhood atopic diseases. The altered metabolic pathways uncover some of the underlying biochem. mechanisms leading to these common childhood disorders, which may become of potential value in clin. practice. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Synthetic Route of 621-37-4
The Article related to review childhood atopic disease metabolomics, asthma, atopy, bile acids, children, lipids, metabolomics, polyunsaturated fatty acids, short-chain fatty acids, tryptophan, tyrosine and other aspects.Synthetic Route of 621-37-4
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts