Kurmaz, Svetlana V.; Fadeeva, Natalia V.; Ignat’ev, Vladislav M.; Kurmaz, Vladimir A.; Kurochkin, Sergei A.; Emel’yanova, Nina S. published an article in 2020, the title of the article was Structure and state of water in branched N-vinylpyrrolidone copolymers as carriers of a hydrophilic biologically active compound.Synthetic Route of 143-10-2 And the article contains the following content:
Hydrated copolymers of N-vinylpyrrolidone (VP) with triethylene glycol dimethacrylate as a promising platform for biol. active compounds (BAC) were investigated by different phys. chem. methods (dynamic light scattering, IR spectroscopy, thermal gravimetric anal., and differential scanning calorimetry) and the quantum chem. modeling of water coordination by the copolymers in a solution According to the quantum chem. simulation, one to two water mols. can coordinate on one O-atom of the lactam ring of VP units in the copolymer. Besides the usual terminal coordination, the water mol. can form bridges to bind two adjacent C=O groups of the lactam rings of VP units. In addition to the first hydration shell, the formation of a second one is also possible due to the chain addition of water mols., and its structure depends on a mutual orientation of C=O groups. We showed that N,N-dimethylbiguanidine hydrochloride (metformin) as a frontline drug for the treatment of type 2 diabetes mellitus can be associated in aqueous solutions with free and hydrated C=O groups of the lactam rings of VP units in studied copolymers. Based on the characteristics of the H-bonds, we believe that the level of the copolymer hydration does not affect the behavior and biol. activity of this drug, but the binding of metformin with the amphiphilic copolymer will delight in the penetration of a hydrophilic drug across a cell membrane to increase its bioavailability. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Synthetic Route of 143-10-2
The Article related to branched vinylpyrrolidone copolymer carrier hydrophilic biol active compound structure, n-vinylpyrrolidone, amphiphilic copolymers, branching, drug delivery, hydrogen bond, metformin, quantum chemical modeling and other aspects.Synthetic Route of 143-10-2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts