Savych, Vladimir I. team published research in Journal of Organic Chemistry in 2021 | 141699-55-0

Related Products of 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

In general, the hydroxyl group makes alcohols polar. 141699-55-0, formula is C8H15NO3, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Related Products of 141699-55-0

Savych, Vladimir I.;Mykhalchuk, Vladimir L.;Melnychuk, Pavlo V.;Isakov, Andrii O.;Savchuk, Taras;Timoshenko, Vadim M.;Siry, Sergiy A.;Pavlenko, Sergiy O.;Kovalenko, Dmytro V.;Hryshchuk, Oleksandr V.;Reznik, Vitalii A.;Chalyk, Bohdan A.;Yarmolchuk, Vladimir S.;Rusanov, Eduard B.;Mykhailiuk, Pavel K. research published 《 Bicyclic Pyrrolidines for Medicinal Chemistry via [3+2]-Cycloaddition》, the research content is summarized as follows. A general approach to bicyclic fused pyrrolidines, e.g., I via [3+2]-cycloaddition between nonstabilized azomethyne ylide and endocyclic electron-deficient alkenes was elaborated. “Push-pull” alkenes and CF3-alkenes did not react with the azomethyne ylide under the previously reported conditions, and a superior protocol (LiF, 140°C, no solvent) developed. Among obtained products were medchem-relevant bicyclic sulfones, mono-fluoro, di-fluoro and trifluoromethyl-substituted pyrrolidines. This approach not only allowed preparation of novel mols., but also significantly simplified synthesis of the existing ones (e.g., Sofinicline).

Related Products of 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts