Noguchi, Tetsuji team published research in Chemical & Pharmaceutical Bulletin in 2006 | 141699-55-0

141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Formula: C8H15NO3

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 141699-55-0, formula is C8H15NO3, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Formula: C8H15NO3

Noguchi, Tetsuji;Tanaka, Naoki;Nishimata, Toyoki;Goto, Riki;Hayakawa, Miho;Sugidachi, Atsuhiro;Ogawa, Taketoshi;Asai, Fumitoshi;Matsui, Yumi;Fujimoto, Koichi research published 《 Indoline derivatives. Synthesis and factor Xa (FXa) inhibitory activities》, the research content is summarized as follows. A series of bisamidine derivatives each having a ring structure in the center of the mol. was synthesized and their Factor Xa (FXa) inhibitory activities were evaluated. Among them, some indoline derivatives showed potent inhibitory activities in vitro. In particular, compound (I) having an (R)-configuration at the 2-position of the indoline ring exhibited the most potent FXa inhibitory activity in vitro, more potent than DX-9065a. Furthermore, I exhibited more potent anticoagulant activity than DX-9065a. The authors also succeeded in obtaining an x-ray crystal structure of FXa bound with I.

141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Formula: C8H15NO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts