Williams, Alexander F.; White, Andrew J. P.; Spivey, Alan C.; Cordier, Christopher J. published an article in 2020, the title of the article was meta-Selective C-H functionalisation of aryl boronic acids directed by a MIDA-derived boronate ester.SDS of cas: 621-37-4 And the article contains the following content:
N-Methyliminodiacetic acid (MIDA) boronates are boronic acid derivatives which are stable to reduction, oxidation and transmetalation. This has led to their widespread use as boronic acid protecting groups (PGs) and in iterative cross-couplings. authors describe herein the development of a novel MIDA derivative that acts in a dual manner, as a protecting group and a directing group (DG) for meta C(sp2)-H functionalisation of arylboronic acids. Palladium catalyzed C-H alkenylations, acetoxylations and arylations are possible, at room temperature and under aerobic conditions. Deprotection to reveal the functionalized boronic acids is rapid and allows for full recovery of the DG. The technique allows the facile diversification of aryl boronic acids and their subsequent use in a range of reactions or in iterative processes. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4
The Article related to methyliminodiacetic acid boronate preparation cross coupling, selective carbon hydrogen functionalization methyliminodiacetic acid boronate ester, palladium catalyzed alkenylation acetoxylation arylation protecting directing group, crystal mol structure methyliminodiacetic acid boronate ester and other aspects.SDS of cas: 621-37-4
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