On January 30, 2022, Tamargo, Alba; Cueva, Carolina; Taladrid, Diego; Khoo, Christina; Moreno-Arribas, M. Victoria; Bartolome, Begona; Gonzalez de Llano, Dolores published an article.Safety of 3-Hydroxyphenylacetic acid The title of the article was Simulated gastrointestinal digestion of cranberry polyphenols under dynamic conditions and its impact on antiadhesive activity against uropathogenic bacteria. And the article contained the following:
This study is the first dynamic simulation of gastrointestinal digestion of cranberry polyphenols [1 g cranberry extract per day (206.2 mg polyphenols) for 18 days]. Samples from the simulated ascending, transverse, and descending colon of the dynamic gastrointestinal simulator simgi were analyzed. Results showed that 67% of the total cranberry polyphenols were recovered after simulated gastrointestinal digestion. Specifically, benzoic acids, hydroxycinnamic acids, phenylpropionic acids, phenylacetic acids, and simple phenols were identified. Cranberry feeding modified colonic microbiota composition of Enterococcaceae population significantly. However, increments in microbial-derived short-chain fatty acids, particularly in butyric acid, were observed Finally, the simgi effluent during cranberry feeding showed significant antiadhesive activity against uropathogenic Escherichia coli (13.7 ± 1.59% of inhibition). Understanding the role that gut microbiota plays in cranberry metabolism could help to elucidate its interaction with the human body and explain cranberry protective effects against urinary tract infections. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Safety of 3-Hydroxyphenylacetic acid
The Article related to cranberry polyphenol metabolite antioxidant renoprotectant urinary tract infection, antiadhesive activity, cranberry, gut microbiota, metabolism, phenolic metabolites, polyphenols, short chain fatty acids (scfas), simgi® model, urinary tract infections (utis), uropathogenic escherichia coli and other aspects.Safety of 3-Hydroxyphenylacetic acid
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