Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 533-73-3, formula is C6H6O3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Category: alcohols-buliding-blocks
Liu, Xingyan;Ma, Shuwei;Huang, Yufeng;Li, Li research published 《 Identification of metabolites of Da Chengqi Tang in human intestinal microflora in vitro by HPLC-QTOF-MS/MS》, the research content is summarized as follows. Objective This study investigated the biotransformation and metabolic profile of Da Chengqi Tang (DCQT) by human intestinal microflora in vitro. Methods DCQT was anaerobically incubated with human intestinal microflora suspensions for 48 h at 37°C. A liquid chromatog.-hybrid quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS/MS) method was developed and applied for rapid identification of the metabolites of DCQT. Results There were 48 compounds identified in DCQT, and 21 metabolites were identified. The possible metabolic pathways, including deglycosylation, glycosylation, methylation, hydration and C ring cleavage of the benzo-γ-pyrone system, were identified. The deglycosylation was the major metabolic pathway of glycosides in DCQT-BT. When DCQT was anaerobically incubated for 48 h by human intestinal microflora, the levels of flavanone glycosides (naringin, hpesperidin and neohesperidin) were decreased continuously (49.56%, 29.25%and 90.95%); the levels of anthraquinones (emodin, physcion and aloe-emodin) were decreased continuously (66.77%, 8.23%and 9.74%); the levels of honokiol and magnolol were decreased continuously (60.01%and 73.80%). At the same time, the metabolites were increased continuously. Conclusion With incubating time prolonging, extensive metabolism of DCQT by human intestinal microflora in vitro was observed Biotransformation of DCQT by human intestinal microflora is beneficial to elevate bioavailability of flavonoid glycosides and metabolites may play a key role in activities of DCQT.
533-73-3, Benzene-1, 2, 4-triol, also known as hydroxyhydroquinone or 1, 2, 4-benzenetriol, belongs to the class of organic compounds known as hydroxyquinols and derivatives. Hydroxyquinols and derivatives are compounds containing a 1, 2, 4-trihydroxybenzene moiety. Benzene-1, 2, 4-triol is soluble (in water) and a very weakly acidic compound (based on its pKa). Outside of the human body, benzene-1, 2, 4-triol can be found in tea. This makes benzene-1, 2, 4-triol a potential biomarker for the consumption of this food product.
Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.
1,2,4-Benzenetriol is a metabolite of benzene.
1,2,4-Benzenetriol is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.
1,2,4-Benzenetriol is a reactive molecule that has been shown to have hydrogen bonding interactions with copper chloride. It has been proposed as an inhibitor of methyltransferase, which is involved in the synthesis of methionine. Studies have shown that 1,2,4-Benzenetriol can also inhibit iron homeostasis and transfer reactions. The x-ray diffraction data for this compound shows that it forms a complex with the hydroxyl group. This complex is stabilized by hydrogen bonding interactions with the hydroxylic proton of the 1,2,4-benzenetriol molecule. 1,2,4-Benzenetriol has been shown to be toxic to HL-60 cells and K562 cells at concentrations greater than 5 mM. It has also been found to be effective against chlorogenic acids and other compounds in energy metabolism studies at concentrations between 0.5 and 2 mM., Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts