Zhao, Fengqian; Ai, Han-Jun; Wu, Xiao-Feng published an article in 2021. The article was titled 《Radical Carbonylation under Low CO Pressure: Synthesis of Esters from Activated Alkylamines at Transition Metal-Free Conditions》, and you may find the article in Chinese Journal of Chemistry.Product Details of 100-55-0 The information in the text is summarized as follows:
High CO pressure (> 40 bar) is usually needed in radical carbonylation reactions in the absence of metal catalyst. In this communication, a transition-metal-free radical carbonylation of activated alkylamines with phenols and alcs. under low CO pressure (1-6 bar) was developed. Various esters were obtained in moderate to excellent yields under simple reaction conditions with good functional group compatibility. After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0Product Details of 100-55-0)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 100-55-0
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts