Reference of Azetidin-3-ol hydrochlorideIn 2014 ,《Discovery of Imigliptin, a Novel Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes》 was published in ACS Medicinal Chemistry Letters. The article was written by Shu, Chutian; Ge, Hu; Song, Michael; Chen, Jyun-hong; Zhou, Huimin; Qi, Qu; Wang, Feng; Ma, Xifeng; Yang, Xiaolei; Zhang, Genyan; Ding, Yanwei; Zhou, Dapeng; Peng, Peng; Shih, Cheng-kon; Xu, Jun; Wu, Frank. The article contains the following contents:
We report our discovery of a novel series of potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors. Starting from a lead identified by scaffold-hopping approach, our discovery and development efforts were focused on exploring structure-activity relationships, optimizing pharmacokinetic profile, improving in vitro and in vivo efficacy, and evaluating safety profile. The selected candidate, Imigliptin, is now undergoing clin. trial. In the experiment, the researchers used Azetidin-3-ol hydrochloride(cas: 18621-18-6Reference of Azetidin-3-ol hydrochloride)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Reference of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
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