Tian, Sinuo; Yan, Sen; Meng, Zhiyuan; Huang, Shiran; Sun, Wei; Jia, Ming; Teng, Miaomiao; Zhou, Zhiqiang; Zhu, Wentao published the artcile< New insights into bisphenols induced obesity in zebrafish (Danio rerio): Activation of cannabinoid receptor CB1>, Application In Synthesis of 492-62-6, the main research area is metabolome bisphenol tetrabromobisphenol cannabinoid CB1 receptor obesity Danio; Bisphenols; Metabolomic modulations; Molecular structure; PCR array; Zebrafish.
Bisphenols (BPs), as widely used plastic additives, penetrate into our daily lives. BPs are considered endocrine disruptors and could potentially induce obesity. In this study, the effects of bisphenol A (BPA) and tetrabromobisphenol A (TBBPA) on food intake and lipid metabolism in zebrafish were determined Moreover, the impact of BPA and TBBPA on the endocannabinoid system (ECS) of zebrafish was further explored by metabolomics, transcriptomics, and mol. docking anal. Here we show that exposure to BPA and TBBPA at concentrations commonly found in the environment (20, 100, and 500μg/L) led to hyperphagia and obesity in adult male zebrafish. Metabolomics and histopathol. anal. revealed significant lipid accumulation in the liver of zebrafish exposed to BPA and TBBPA. The expression of ECS-related genes, in conjunction with RNA-Seq results, further indicated that BPA and TBBPA increased appetite and induced obesity by activating cannabinoid receptor type 1(CB1). Furthermore, mol. docking revealed that six representative BPs including BPA and TBBPA could bind to the CB1 receptor. Collectively, these findings indicate that CB1 may be a potential target for BPs to induce obesity.
Journal of Hazardous Materials published new progress about Adult, nonmammalian. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 492-62-6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts