Liu, Gang; Kim, Hyejin; Wang, Pingyuan; Fricke, Doerte R.; Chen, Haiying; Wang, Tianzhi; Shen, Qiang; Zhou, Jia published an article in 2021. The article was titled 《Further lead optimization on Bax activators: Design, synthesis and pharmacological evaluation of 2-fluoro-fluorene derivatives for the treatment of breast cancer》, and you may find the article in European Journal of Medicinal Chemistry.HPLC of Formula: 100-55-0 The information in the text is summarized as follows:
Fluorofluorene I exhibited a good balance between antitumor activity and toxicity, displaying submicromolar activities against a variety of cancer cell lines with 5.8-10.7-fold selectivity of decreased activity to MCF-10A human mammary epithelial cell line. Compound I dose-dependently blocked colony formation of breast cancer cells and prevented the migration and invasion of MDA-MB-231 cells. Mechanism of action studies indicate that I activated Bax, rendering its insertion into mitochondrial membrane, thereby leading to cytochrome c release from the mitochondria into the cytoplasm, subsequently inducing release of apoptotic biomarkers. Further in vivo efficacy studies of I in human breast cancer xenografts arisen from MDA-MB-231 cells demonstrated that this drug candidate significantly suppressed tumor growth, indicating the therapeutic promise of this class of compounds for the treatment of breast cancer as well as the potential for developing F-radiolabeled imaging ligands as anticancer chem. probes. After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0HPLC of Formula: 100-55-0)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 100-55-0
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