Bharate, Sandip B.; Mudududdla, Ramesh; Bharate, Jaideep B.; Battini, Narsaiah; Battula, Satyanarayana; Yadav, Rammohan R.; Singh, Baldev; Vishwakarma, Ram A. published the artcile< Tandem one-pot synthesis of flavans by recyclable silica-HClO4 catalyzed Knoevenagel condensation and [4 + 2]-Diels-Alder cycloaddition>, Product Details of C8H6O5, the main research area is flavan preparation Knoevenagel condensation Diels Alder silica perchloric acid.
An efficient one-pot multi-component synthesis of flavans, e.g., I, using perchloric acid supported on silica as a recyclable heterogeneous catalyst has been described. This is the first report of direct one-step construction of a flavan skeleton from a phenolic precursor, e.g., II. The method involves a Knoevenagel-type condensation leading to in situ formation of transient O-quinone methide which further undergoes [4 + 2]-Diels-Alder cycloaddition with styrene, e.g., 4-H2C:CHC6H4CMe3, to yield a flavan skeleton. The method provides easy access to a wide range of bio-active natural products viz. flavonoids, anthocyanins and catechins.
Organic & Biomolecular Chemistry published new progress about Diels-Alder reaction. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Product Details of C8H6O5.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts