Bai, Renren; Zhu, Junlong; Bai, Ziqiang; Mao, Qing; Zhang, Yingqian; Hui, Zi; Luo, Xinyu; Ye, Xiang-Yang; Xie, Tian published the artcile< Second generation β-elemene nitric oxide derivatives with reasonable linkers: potential hybrids against malignant brain glioma>, Computed Properties of 699-12-7, the main research area is beta elemene nitric oxide malignant brain glioma antitumor; NO donor; anti-tumour; malignant glioma; natural product; β-Elemene.
Elemene is a second-line broad-spectrum anti-tumor drug that has been used in China for more than two decades. However, its main anti-tumor ingredient, β-elemene, has disadvantages, including excessive lipophilicity and relatively weak anti-tumor efficacy. To improve the anti-tumor activity of β-elemene, based on its minor mol. weight character, we introduced furoxan nitric oxide (NO) donors into the β-elemene structure and designed six series of new generation β-elemene NO donor hybrids. The synthesized compounds could effectively release NO in vitro, displayed significant anti-proliferative effects on U87MG, NCI-H520, and SW620 cell lines. In the orthotopic glioma model, compound significantly and continuously suppressed the growth of gliomas in nude mice, and the brain glioma of the treatment group was markedly inhibited (>90%). In short, the structural fusion design of NO donor and β-elemene is a feasible strategy to improve the in vivo anti-tumor activity of β-elemene.
Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Amidation. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Computed Properties of 699-12-7.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts