Application In Synthesis of 3-PyridinemethanolIn 2019 ,《Synthesis and antitumor activity of novel pyridinium fullerene derivatives》 appeared in International Journal of Nanomedicine. The author of the article were Yasuno, Takumi; Ohe, Tomoyuki; Ikeda, Hitomi; Takahashi, Kyoko; Nakamura, Shigeo; Mashino, Tadahiko. The article conveys some information:
Nineteen pyridinium fullerene derivatives were newly designed and synthesized in this study. Their antiproliferative activities were evaluated using several cancer cell lines including drug-resistant cells. Furthermore, in-vivo antitumor activity of several derivatives was investigated in mouse xenograft model of human lung cancer. The derivatives inhibited the proliferation of cancer cell lines, including cisplatin resistant cells and doxorubicin-resistant cells. It was also shown that compounds I (10μM), II (10μM) and III (10μM) induced the intracellular oxidative stress. In addition, compound III (20 mg/kg) and cis-14 (15 mg/kg) significantly exhibited antitumor activity in mouse xenograft model of human lung cancer. These fullerene derivatives served as the lead compounds for a novel type of antitumor agents . The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Application In Synthesis of 3-Pyridinemethanol)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 3-Pyridinemethanol
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