Sharma, Rohit; Abbat, Sheenu; Mudududdla, Ramesh; Vishwakarma, Ram A.; Bharatam, Prasad V.; Bharate, Sandip B. published the artcile< ortho-Quinone methides: TFA-mediated generation in water and trapping with lactams and styrenes>, Formula: C8H6O5, the main research area is quinone methide TFA generation water trapping lactam styrene.
A simple and efficient trifluoroacetic acid mediated protocol for ortho-amidomethylation of phenols in aqueous medium was described. Developed protocol has a good substrate scope, involves mild reaction conditions, and products are obtained in good yields. The quantum chem. calculations were performed in implicit solvent (water) conditions, which helped in tracing the reaction mechanism and getting insights on the possible reaction pathway, which involves the N-C bond formation and simultaneous hydrogen transfer to give final product. The applicability of this protocol for 1-pot synthesis of flavans from phenols, formaldehyde and styrene also was demonstrated.
Tetrahedron Letters published new progress about Cycloaddition reaction. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Formula: C8H6O5.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts