Category: alcohols-buliding-blocksIn 2019 ,《Concise Syntheses of Δ12-Prostaglandin J Natural Products via Stereoretentive Metathesis》 appeared in Journal of the American Chemical Society. The author of the article were Li, Jiaming; Ahmed, Tonia S.; Xu, Chen; Stoltz, Brian M.; Grubbs, Robert H.. The article conveys some information:
The Δ12-Prostaglandin J family was recently discovered and has potent anticancer activity. Concise syntheses of four Δ12-prostaglandin J natural products (7-8 steps in the longest linear sequences), I, II, III, and IV, are reported, enabled by convergent stereoretentive cross-metathesis. Exceptional control of alkene geometry was achieved through stereoretention. In the experiment, the researchers used 5-Hexen-1-ol(cas: 821-41-0Category: alcohols-buliding-blocks)
5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts