In 2022,Jud, Wolfgang; Salazar, Chase A.; Imbrogno, Joseph; Verghese, Jenson; Guinness, Steven M.; Desrosiers, Jean-Nicolas; Kappe, C. Oliver; Cantillo, David published an article in Organic Process Research & Development. The title of the article was 《Electrochemical Oxidation of Alcohols Using Nickel Oxide Hydroxide as Heterogeneous Electrocatalyst in Batch and Continuous Flow》.Recommanded Product: 3-Pyridinemethanol The author mentioned the following in the article:
An electrochem. method was developed for a mediated oxidation of primary alcs. to carboxylic acids. The method is compatible with a variety of alcs. bearing N-containing heterocycles in undivided batch and flow modes. The use of a heterogeneous NiOOH electron-proton transfer mediator avoids the need for homogeneous catalysts that contribute to more unit operations during downstream purging and increased process mass intensity. To demonstrate the applicability of this method for continuous processing, a single-pass flow electrochem. oxidation of nicotinyl alc. to nicotinic acid is demonstrated with a 77% isolated yield. The NiOOH-coated anodes show no reduction in catalysis efficiency over 12 h, and minimal Ni metal leaching (22.3μg per L) is observed The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 3-Pyridinemethanol)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Recommanded Product: 3-Pyridinemethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts