COA of Formula: C6H7NOIn 2020 ,《Quantitative perspective on online flow reaction profiling using a miniature mass spectrometer》 appeared in Organic Process Research & Development. The author of the article were Sheng, Huaming; Corcoran, Emily B.; Dance, Zachary E. X.; Smith, Joseph P.; Lin, Zhihao; Ordsmith, Victoria; Hamilton, Simon; Zhuang, Ping. The article conveys some information:
Online mass spectrometry has proven to be a useful tool for characterizing many aspects of chem. reactions. However, to the best of the authors’ knowledge, no reference standard (RS) quantitation approach has been applied in online MS profiling work to date. In this study, we present a RS approach for online quantitation of an aerobic oxidation reaction in flow using a miniature mass spectrometer, with both internal RS and external RS quantitation approaches being evaluated. Quinoline, a structurally similar and chem. inert compound under these reaction conditions, was chosen as the RS to quantify the pyridine aldehyde product. To investigate the optimal RS concentration and instrument attenuation, calibration curves were established by plotting the product/RS peak intensity ratio against the theor. product yield at different attenuation (dilution factor) values. The MS quantitation results for the actual flow reactions were validated with conventional offline 1H NMR anal. In the experimental materials used by the author, we found 3-Pyridinemethanol(cas: 100-55-0COA of Formula: C6H7NO)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C6H7NO
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