Application In Synthesis of 5-Hexen-1-olIn 2019 ,《Aryl Boronic Acid Catalysed Dehydrative Substitution of Benzylic Alcohols for C-O Bond Formation》 was published in Chemistry – A European Journal. The article was written by Estopina-Duran, Susana; Donnelly, Liam J.; McLean, Euan B.; Hockin, Bryony M.; Slawin, Alexandra M. Z.; Taylor, James E.. The article contains the following contents:
A combination of pentafluorophenylboronic acid and oxalic acid catalyzed the dehydrative substitution of benzylic alcs. with a second alc. to form new C-O bonds. This method had been applied to the intermol. substitution of benzylic alcs. to form sym. ethers I [R = H, Ph; Ar = Ph, 2-ClC6H4, 4-BrC6H4, etc.], intramol. cyclizations of diols to form aryl-substituted THF and tetrahydropyran derivatives II [Q = (CH2)n, n = 1,2; Ar = 4-MeOC6H4, 4-F3CC6H4], and intermol. crossed-etherification reactions between two different alcs. to give unsym. ethers III [R1 = Et, sec-Bu, 5-hexen-1-yl, etc.; R2 = Me, i-Pr, t-Bu, ethynyl, Ph; Ar = 3-BrC6H4, 2-MeOC6H4]. Mechanistic control experiments had identified a potential catalytic intermediate formed between the aryl boronic acid and oxalic acid. In the experiment, the researchers used many compounds, for example, 5-Hexen-1-ol(cas: 821-41-0Application In Synthesis of 5-Hexen-1-ol)
5-Hexen-1-ol(cas: 821-41-0) is used in cyclization to a tetrahydropyran by phenylselenoetherification. It is also used as a building block in synthetic chemistry.Application In Synthesis of 5-Hexen-1-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts