Safety of 3-PyridinemethanolIn 2020 ,《Nickel-Catalyzed Synthesis of Pyrimidines via Dehydrogenative Functionalization of Alcohols》 appeared in Asian Journal of Organic Chemistry. The author of the article were Chakraborty, Gargi; Sikari, Rina; Mondal, Rakesh; Mandal, Sutanuva; Paul, Nanda D.. The article conveys some information:
Herein, a comparative study of nickel-catalyzed syntheses of pyrimidines via dehydrogenative multi-component coupling of alcs. and amidines using two different classes of nickel catalysts differing with respect to their mode of action during catalysis is reported. The catalysts are either two tetracoordinate Ni(II)-complexes containing two apparently redox-inactive tetraaza macrocyclic ligands or square planar Ni(II)-complexes featuring redox-active diiminosemiquinonato type scaffolds. Tetracoordinate Ni(II) catalysts dehydrogenate alcs. via a two-electron hydride transfer pathway involving energetically demanding nickel-centered redox events while in the presence of square planar Ni(II)-complexes dehydrogenation of alcs. proceeds via a one-electron hydrogen atom transfer (HAT) pathway via synergistic participation of metal and ligand centered redox processes avoiding high energy nickel centered redox events. Detailed substrate screening and control experiments were performed to unveil the reaction sequence and understand the advantages/disadvantages of these two pathways. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0Safety of 3-Pyridinemethanol)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Safety of 3-Pyridinemethanol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts