SDS of cas: 100-55-0In 2021 ,《Synthesis of bioactive quinoline acting as anticancer agents and their mode of action using in silico analysis towards Aurora kinase A inhibitors》 appeared in Chemical Data Collections. The author of the article were Narasimhamurthy, Kereyagalahally H.; Guruswamy, Dileep Kumar M.; Chandra; Kallesha, Nichhapurada; Basappa; Rangappa, Kanchugarakoppal S.. The article conveys some information:
In the present investigation, novel quinolines have been synthesized and analyzed for their invitro cytotoxic activity against human colon cancer and lung cancer cells. Among the newly synthesized quinoline derivatives, 2-(3-chlorophenyl)-6,7-dimethoxyquinoline (Q6) showed considerable cytotoxic activity against human colon cancer (HCT116) and lung cancer (A549) cell lines with IC50 values of 25.5 ± 2.7 and 32 ± 4.7 μM resp. Since these quinolines interacted with an Aurora kinase A, we carried out the mol. docking investigation and observed that this quinoline displayed inhibitory potentials. Overall, the compound Q6 was well suited to develop a newer quinolines-based anticancer medication, especially to block cell cycle arrest through Aurora kinase A inhibitors in human cancer.3-Pyridinemethanol(cas: 100-55-0SDS of cas: 100-55-0) was used in this study.
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. SDS of cas: 100-55-0
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