Ghlissi, Zohra; Kallel, Rim; Krichen, Fatma; Hakim, Ahmed; Zeghal, Khaled; Boudawara, Tahiya; Bougatef, Ali; Sahnoun, Zouheir published the artcile< Polysaccharide from Pimpinella anisum seeds: Structural characterization, anti-inflammatory and laser burn wound healing in mice>, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol, the main research area is Staphylococcus Pimpinella laser burn wound healing seed polysaccharide antiinflammatory; Anti-inflammatory activity; Laser burn; Pimpinella anisum; Polysaccharide; Wound healing.
The polysaccharide preparation from Pimpinella anisum seeds (PAP) was isolated and characterized to evaluate its laser burn wound-healing and anti-inflammatory activities in mice. The structure characterization of PAP by Infra-red spectrometry (IR), NMR (NMR), Gas chromatogram-Mass spectrometer (GC-MS) and colorimetric methods revealed an optimum yield of 8.84%, a high quantity of carbohydrate (64.75%) and low levels of lipids, protein and sulfate. Galactose (33.47%), β-D-Glucose (26.71%) and a-D-Mannose (18.21%) were the major monosaccharides components presenting in PAP, and a smaller amounts of β-D-Galactose, D-Fructose, a-D-Glucose, a-L-Galactose and arabinose were detected. PAP showed noticeable antioxidant and antibacterial properties. The anti-inflammatory activity of PAP in the carrageenan-induced paw edema model in mice, demonstrated by reduced edema and cellular infiltration, and oxidative stress markers in muscle tissue. A beneficial wound healing effect was also revealed. The topical application of PAP based gel on laser burn lesions accelerates wound contraction, the re-epithelization and remodeling phases after seven days of treatment. The results demonstrated that PAP is a novel promising source of natural wound healing and anti-inflammatory drugs. The high content and varied PAP monosaccharides seem to be responsible for the observed biol. activities.
International Journal of Biological Macromolecules published new progress about Anti-inflammatory agents. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Name: (2S,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts