Category: alcohols-buliding-blocksIn 2019 ,《Iron-catalyzed regioselective cyclotrimerization of alkynes to benzenes》 appeared in Journal of Organometallic Chemistry. The author of the article were Gawali, Suhas Shahaji; Gunanathan, Chidambaram. The article conveys some information:
We report the synthesis and characterization of simple di(aminomethyl)pyridine ligated iron-pincer complexes, which catalyzed the regioselective [2+2+2]-cyclotrimerization of terminal aryl and alkyl alkynes to provide the 1,2,4-trisubstituted benzene mols. Interestingly, internal alkynes also exhibited similar cyclization and resulted in hexa-substituted benzene compounds Increased steric bulk on pincer ligands diminished the selectivity for cycloaddition Cyclotrimerization reactions proceeded at room temperature upon activation of catalyst by a Grignard reagent. EPR studies indicated thermally induced spin crossover effect in catalyst. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Category: alcohols-buliding-blocks) was used in this study.
2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts