In 2022,Cleveland, Jacob W.; Choi, Ji Il; Sekiya, Ryoh-Suke; Cho, Jinwon; Moon, Hyun June; Jang, Seung Soon; Jones, Christopher W. published an article in ACS Applied Materials & Interfaces. The title of the article was 《Cooperativity in the Aldol Condensation Using Bifunctional Mesoporous Silica-Poly(styrene) MCM-41 Organic/Inorganic Hybrid Catalysts》.Synthetic Route of C6H12O The author mentioned the following in the article:
This work explores the efficacy of silica/organic hybrid catalysts, where the organic component is built from linear aminopolymers appended to the silica support within the support mesopores. Specifically, the role of mol. weight and polymer chain composition in amine-bearing atom transfer radical polymerization-synthesized poly(styrene-co-2-(4-vinylbenzyl)isoindoline-1,3-dione) copolymers is probed in the aldol condensation of 4-nitrobenzaldehyde and acetone. Controlled polymerization produces protected amine-containing poly(styrene) chains of controlled mol. weight and dispersity, and a grafting-to thiol-ene coupling approach followed by a phthalimide deprotection step are used to covalently tether and activate the polymer hybrid catalysts prior to the catalytic reactions. Site-normalized batch kinetics are used to assess the role of polymer mol. weight and chain composition in the cooperative catalysis. Lower-mol.-weight copolymers are demonstrated to be more active than catalysts built from only mol. organic components or from higher-mol.-weight chains. Mol. dynamics simulations are used to probe the role of polymer flexibility and morphol., whereby it is determined that higher-mol.-weight hybrid structures result in congested pores that inhibit active site cooperativity and the diffusivity of reagents, thus resulting in lower rates during the reaction.5-Hexen-1-ol(cas: 821-41-0Synthetic Route of C6H12O) was used in this study.
5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Synthetic Route of C6H12O
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