Campbell, Mark W.; Polites, Viktor C.; Patel, Shivani; Lipson, Juliette E.; Majhi, Jadab; Molander, Gary A. published an article in 2021. The article was titled 《Photochemical C-F activation enables defluorinative alkylation of trifluoroacetates and -acetamides》, and you may find the article in Journal of the American Chemical Society.Name: 5-Hexen-1-ol The information in the text is summarized as follows:
The installation of gem-difluoromethylene groups into organic structures remains a daunting synthetic challenge despite their attractive structural, phys., and biochem. properties. A very efficient retrosynthetic approach would be the functionalization of a single C-F bond from a trifluoromethyl group. Recent advances in this line of attack have enabled the C-F activation of trifluoromethylarenes, but limit the accessible motifs to only benzylic gem-difluorinated scaffolds. In contrast, the C-F activation of trifluoroacetates would enable their use as a bifunctional gem-difluoromethylene synthon. Herein, we report a photochem. mediated method for the defluorinative alkylation of a commodity feedstock: Et trifluoroacetate. A novel mechanistic approach was identified using our previously developed diaryl ketone HAT catalyst to enable the hydroalkylation of a diverse suite of alkenes. Furthermore, electrochem. studies revealed that more challenging radical precursors, namely trifluoroacetamides, could also be functionalized via synergistic Lewis acid/photochem. activation. Finally, this method enabled a concise synthetic approach to novel gem-difluoro analogs of FDA-approved pharmaceutical compounds5-Hexen-1-ol(cas: 821-41-0Name: 5-Hexen-1-ol) was used in this study.
5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Name: 5-Hexen-1-ol
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