Monticelli, Serena; Urban, Ernst; Langer, Thierry; Holzer, Wolfgang; Pace, Vittorio published the artcile< A Straightforward Homologation of Carbon Dioxide with Magnesium Carbenoids en Route to α-Halocarboxylic Acids>, Reference of 699-12-7, the main research area is halo carboxylic acid preparation green chem diastereoselective chemoselective; magnesium carbenoid chloro sulfoxide carbon dioxide nucleophilic addition; dihalo carboxylic acid preparation green chem chemoselective; dihalomethane magnesium carbenoid carbon dioxide nucleophilic addition.
The homologation of carbon dioxide with stable, (enantiopure) magnesium carbenoids constitutes a valuable method for preparing α-halo acid derivatives RR1C(COOH)Cl (R = H, Et, 2,6-dimethylbenzyl, thiophen-2-ylmethyl, etc.; RR1 = -(CH2)2-; X = Cl, Br, I), 2-chloroacrylic acid and α, α-dihalo carboxylic acids XCH(Y)COOH (X = Cl, Br, I; Y = Cl, Br, I). The tactic features a high level of chemocontrol, thus enabling the synthesis of variously functionalized analogs. such as 1-chloro-2-(methoxycarbonyl)-2-methylcyclopropanecarboxylic acid and 1-chloro-2-methyl-1,2-cyclopropanedicarboxylic acid. The flexibility to generate magnesium carbenoids through sulfoxide-, halogen- or proton- Mg exchange accounts for the wide scope of the reaction.
Advanced Synthesis & Catalysis published new progress about Chemoselectivity. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Reference of 699-12-7.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts