Intermaggio, Nicholas E.; Millet, Agustin; Davis, Dali L.; MacMillan, David W. C. published an article in 2022. The article was titled 《Deoxytrifluoromethylation of Alcohols》, and you may find the article in Journal of the American Chemical Society.Product Details of 100-55-0 The information in the text is summarized as follows:
Deoxy-functionalization of alcs. represents a class of reactions that has had profound impact on modern medicine. In particular, deoxyfluorination is commonly employed as a means to incorporate high-value fluorine atoms into drug-like mols. Recently, the trifluoromethyl (CF3) group has garnered attention from medicinal chemists due to its ability to markedly improve the pharmaceutical properties of small mol. drug candidates. To date, however, there remains no general means to accomplish the analogous deoxygenative trifluoromethylation of alcs. Herein, a copper metallaphotoredox-mediated direct deoxytrifluoromethylation is reported, wherein alc. substrates are activated in situ by benzoxazolium salts for C(sp3)-CF3 bond formation. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Product Details of 100-55-0)
3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Product Details of 100-55-0
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts