Bhatta, Rimsha; Han, Joonsu; Zhou, Jingyi; Li, Haoyu; Wang, Hua published the artcile< Recyclable cell-surface chemical tags for repetitive cancer targeting>, Application of C6H14ClNO5, the main research area is recyclable cell surface chem tag repetitive cancer targeting; Cell targeting; Chemotherapy; Click chemistry; Metabolic glycan labeling; cancer.
Metabolic glycan labeling provides a facile yet powerful tool to install chem. tags to the cell membrane via metabolic glycoengineering processes of unnatural sugars. These cell-surface chem. tags can then mediate targeted conjugation of therapeutic agents via efficient chemistries, which has been extensively explored for cancer-targeted treatment. However, the commonly used in vivo chemistries such as azide-cyclooctyne and tetrazine-cyclooctene chemistries only allow for one-time use of cell-surface chem. tags, posing a challenge for long-term, continuous cell targeting. Here we show that cell-surface ketone groups can be recycled back to the cell membrane after covalent conjugation with hydrazide-bearing mols., enabling repetitive targeting of hydrazide-bearing agents. Upon conjugation to ketone-labeled cancer cells via a pH-responsive hydrazone linkage, Alexa Fluor 488-hydrazide became internalized and entered endosomes/lysosomes where ketone-sugars can be released and recycled. The recycled ketone groups could then mediate targeted conjugation of Alexa Fluor 647-hydrazide. We also showed that doxorubicin-hydrazide can be targeted to ketone-labeled cancer cells for enhanced cancer cell killing. This study validates the recyclability of cell-surface chem. tags for repetitive targeting of cancer cells with the use of a reversible chem., which will greatly facilitate future development of potent cancer-targeted therapies based on metabolic glycan labeling.
Journal of Controlled Release published new progress about Antitumor agents. 5505-63-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H14ClNO5, Application of C6H14ClNO5.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts