《Phosphonate inhibitors of West Nile virus NS2B/NS3 protease》 was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. These research results belong to Skorenski, Marcin; Milewska, Aleksandra; Pyrc, Krzysztof; Sienczyk, Marcin; Oleksyszyn, Jozef. Synthetic Route of C8H19NO2 The article mentions the following:
West Nile virus (WNV) is a member of the flavivirus genus belonging to the Flaviviridae family. The viral serine protease NS2B/NS3 has been considered an attractive target for the development of anti-WNV agents. Although several NS2B/NS3 protease inhibitors have been described so far, most of them are reversible inhibitors. Herein, we present a series of α-aminoalkylphosphonate di-Ph esters and their peptidyl derivatives as potent inhibitors of the NS2B/NS3 protease. The most potent inhibitor identified was Cbz-Lys-Arg-(4-GuPhe)P(OPh)2 displaying Ki and k2/Ki values of 0.4 μM and 28 265 M-1s-1, resp., with no significant inhibition of trypsin, cathepsin G, and HAT protease. In the part of experimental materials, we found many familiar compounds, such as 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Synthetic Route of C8H19NO2)
4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Synthetic Route of C8H19NO2
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