I found the field of Chemistry very interesting. Saw the article Stereoselective 1,4-Addition of Primary Alcohols to gamma-Alkoxy-alpha,beta-unsaturated Esters published in 2021. Safety of (4-Methoxyphenyl)methanol, Reprint Addresses Nakamura, S (corresponding author), Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, 3-1 Tanabe Dori, Nagoya, Aichi 4678603, Japan.. The CAS is 105-13-5. Through research, I have a further understanding and discovery of (4-Methoxyphenyl)methanol
The scope and limitations of the diastereoselective 1,4-addition reaction of primary alcohols to gamma-alkoxy-alpha,beta-unsaturated esters were investigated. We found that a variety of sodium alkoxides, generated from the corresponding primary alcohols with NaH, underwent 1,4-addition reactions with (E)-enoates in CH(2)Cl(2)at -23 degrees C to give beta-alkoxy esters in modest yields with good to excellentsyn-selectivity, whereas stereoselectivity was not observed with the use of glycerol derivatives as nucleophiles. Cyclic acetal protection was found to play a pivotal role for the reaction to proceed.
Welcome to talk about 105-13-5, If you have any questions, you can contact Inatomi, S; Takayanagi, Y; Watanabe, K; Toita, A; Yamakoshi, H; Nakamura, S or send Email.. Safety of (4-Methoxyphenyl)methanol
Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts