Electric Literature of 75476-86-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 75476-86-7, name is 6-Bromo-2,3-dihydro-1H-inden-1-ol. A new synthetic method of this compound is introduced below.
To a solution of 6-bromo-2,3-dihydro-1 H-inden-1 -ol (1 .50 g, 7.04 mmol) in DOM (3.5 mL) wasadded thionyl chloride (1.028 mL, 14.08 mmol). The resulting reaction mixture was stirred atambient temperature for 1 h. The reaction mixture was evaporated under vacuum to afford product 6-bromo-1-chloro-2,3-dihydro-1 H-indene (1.6225 g, 7.01 mmol, 100% yield). 1H NMR (400 MHz, CHLOROFORM-d) ppm 2.33- 2.44 (m, 1 H) 2.63 (dq, J=14.24, 7.22 Hz, 1 H) 2.86 (ddd, J=1 6.00, 7.97, 4.14 Hz, 1 H) 3.13 (dt, J=1 5.81, 7.65 Hz, 1 H) 5.37 (dd, J=6.53, 3.51 Hz, 1H) 7.14 (d, J=8.03 Hz, 1 H) 7.39 (d, J=8.03 Hz, 1 H) 7.57 (s, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75476-86-7, its application will become more common.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ASTEX THERAPEUTICS LIMITED; KERNS, Jeffrey K.; YAN, Hongxing; CALLAHAN, James Francis; HEIGHTMAN, Thomas Daniel; BOEHM, Jeffrey Charles; WOOLFORD, Alison Jo-Anne; (250 pag.)WO2016/203401; (2016); A1;,
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