Electric Literature of 575-03-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 575-03-1, name is 7-Hydroxy-4-(trifluoromethyl)coumarin, molecular formula is C10H5F3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Commercially available 7-hydroxy-4-trifluoromethyl coumarin (0.069g, 0.30mmol) was dissolved in dry DMF (2.0mL) and then 60percent NaH in mineral oil (0.012g, 0.30mmol) was added while cooling at 0°C. The mixture was slowly warmed at room temperature, then 3-chlorobenzyl bromide (0.040mL, 0.30mmol) was added dropwise via syringe after 1h and stirring was continued for 24h at room temperature. After addition of crushed ice, the suspension was treated with 2.0N aq. solution of NaOH (5mL). The mixture was stirred for 1h and the resulting precipitate was filtered and washed with water, yielding compound 24. White crystals; yield: 84percent, mp: 118.8?120.3°C (ethanol). 1H NMR (300MHz, DMSO-d6) delta: 5.27 (s, 2H), 6.85 (s, 1H), 7.13 (dd, J1=2.4Hz, J2=8.9Hz, 1H), 7.23 (d, J=2.4Hz, 1H), 7.40?7.45 (m, 3H), 7.54 (s, 1H), 7.61?7.64 (m, 1H). Anal. (C17H10ClF3O3) C, H.
According to the analysis of related databases, 575-03-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Grossi, Giancarlo; Di Braccio, Mario; Soto-Otero, Ramon; Mendez-Alvarez, Estefania; Stefanachi, Angela; Gadaleta, Domenico; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 723 – 739;,
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