Month: July 2021

Application of 42142-52-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 42142-52-9, name is 3-(Methylamino)-1-phenylpropan-1-ol, molecular formula is C10H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of N-methy-3-phenyl-3-hydroxy phenylpropylamine (25 g, 0.15 mole) in hexamethylphosphorous triamide and potassium tertiary butoxide (19 g, 0.17 mole) at 50-60C was charged 2-flourotoluene (50 g, 0.45 mole) and the contents of the reaction were heated to 105-110C. The reaction was maintained for 19-20 hours. After the completion of the reaction (checked by TLC) there were charged water (250 ml) followed by toluene (250 ml) and the mixture was stirred for 10-15 minutes. The aqueous and organic layers were separated, then the aqueous layer was extracted with toluene (2×75 ml). Thecombined organic layer was washed with water (3×75 ml) and then subjected to distillation to obtain a thick residue. The residue was dissolved in acetone (150 ml) followed by adding oxalic acid and isopropyl ether (200 ml) and the mixture was stirred for 1-1.5 hours at 0-5C, then the obtained solid was separated by filtration and washing with isopropyl ether (100 ml) resulting in the oxalate of atomoxetine. Yield 62.4% and HPLC purity 95.4%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 42142-52-9, 3-(Methylamino)-1-phenylpropan-1-ol.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; WO2006/9884; (2006); A1;,
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Related Products of 2919-23-5 , The common heterocyclic compound, 2919-23-5, name is Cyclobutanol, molecular formula is C4H8O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-Bromo-6-chloronicotinic acid (CAN 29241-62-1, 2.0 g, 8.46 mmol) was dissolved in DMSO (20.0 mL). Cyclobutanol (793 mg, 857 muL, 11.0 mmol) and potassium hydroxide powder (1.42 g, 25.4 mmol) were added and the mixture was stirred at room temperature overnight. Water (20 mL) was added and the mixture was acidified (under ice-water bath cooling) with 37% HCL in water (pH=2). The suspension was filtered, washed with water and the solid was dried to yield 1.88 g (82%) of the title compound as a white solid; MS (ESI): 270.2 (M-H)-.

The synthetic route of 2919-23-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hebeisen, Paul; Matile, Hugues; Roever, Stephan; Wright, Matthew; Jensen, Sannah Zoffmann; US2012/65212; (2012); A1;,
Alcohol – Wikipedia,
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Application of 65735-71-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 65735-71-9, name is (4-Chloro-3-(trifluoromethyl)phenyl)methanol, molecular formula is C8H6ClF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(4-Chloro-3-(trifluoromethyl)phenyl)methanol (5.1 g, 24.22 mmol) was added in small portions to SOCl2 (20 mL, 275 mmol). The reaction was stirred at 50 0C for 18 h and then under reflux for 23 h. The mixture was concentrated and dried under high vacuum to give the title compound as a colorless liquid (5.41 g). 1H NMR (400 MHz, CDCl3) delta ppm 4.58 (s, 2H), 7.50- 7.51(1-1, 2H), 7.71 (s, IH).

According to the analysis of related databases, 65735-71-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; BUZARD, Daniel J.; SCHRADER, Thomas O.; KASEM, Michelle; ZHU, Xiuwen; JOHNSON, Benjamin R.; LEHMANN, Juerg; HAN, Sangdon; KAWASAKI, Andrew M.; WO2011/5295; (2011); A1;,
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Synthetic Route of 4415-82-1 ,Some common heterocyclic compound, 4415-82-1, molecular formula is C5H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of Pyridinium chiorochromate (41.3 g, 191.6 mmol) in dichioromethane (120 mL) was added Cyclobutanemethanol (7.5 g, 87.1 mmol). The mixture was stirred fbr 1.5 hours then filtered through a pad of silica and rinsed with further dichioromethane (300 rnL). The solvent was removed under reduced pressure to give 2-cyciobutylcarbaldehyde (10,0 g, contains residual dichioromethane) that wasused without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4415-82-1, Cyclobutylmethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ALKERMES PHARMA IRELAND LIMTED; DEAVER, Dan; BLUMBERG, Laura, Cook; EYERMAN, David; WYNN, Thomas; WO2014/190271; (2014); A2;,
Alcohol – Wikipedia,
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Electric Literature of 929-06-6 , The common heterocyclic compound, 929-06-6, name is 2-(2-Aminoethoxy)ethanol, molecular formula is C4H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis of 3,6,11-trioxa-9-azatridecanoic acid, 12,12-dimethyl-10-oxo-, methyl ester (17) To a stirred solution of 2-(2-aminoethoxyl)ethanol (1.05 g, 10 mmol, 1 equiv) in anhydrous ethanol (15 mL) at 0 C. was added di-tert-butyl dicarbonate (2.2 g, 10 mmol, 1 equiv). The reaction mixture was stirred for 2 hours at room temperature. It was concentrated under reduced pressure, re-dissolved in dichloromethane, and washed with brine. The organic extract was dried over anhydrous sodium sulfate and the solvent was removed under reduced pressure to give the crude product as a colorless oil. The product 12 was used in the next step without further purification. 1H NMR (600 MHz, CDCl3) delta 1.44 (s, 9H), 3.33-3.34 (m, 2H), 3.54-3.59 (dt, J=10.4, 5.2 Hz, 2H), 3.73-3.75 (dt, J=4.3, 3.4 Hz, 2H).

The synthetic route of 929-06-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE UNIVERSITY OF TOLEDO; Tillekeratne, L. M. Viranga; Almaliti, Jehad; Al-Hamashi, Ayad; Bhansali, Pravin; (74 pag.)US2015/329560; (2015); A1;,
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Synthetic Route of 101597-25-5 ,Some common heterocyclic compound, 101597-25-5, molecular formula is C17H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(synthesis of chromene compound) [0128] 1.18 g (2.0 mmol) of the above naphthol compound (15) and 0.81 g (3.0 mmol) of the following propargyl alcohol compound were dissolved in 50 ml of toluene, and 0.02 g of camphorsulfonic acid was added to the resulting solution and stirred under heating and reflux for 1 hour. After a reaction, the solvent was removed, and the obtained reaction product was purified by chromatography on silica gel to obtain 1.17 g of a white powder product. The yield was 70 %. [0129] The elemental analysis values of this product were 84.59 % of C and 5.93 % of H which were almost equal to the calculated values of C59H50O5 (C: 84.46 %, H: 6.01 %). [0130] When the proton nuclear magnetic resonance spectrum of the product was measured, it showed 20H peaks based on a methyl proton and a methylene proton at delta of around 1.0 to 4.0 ppm and 30H peaks based on an aromatic proton and an alkene proton at delta of around 5.5 to 9.0 ppm. [0131] Further, when the 13C-nuclear magnetic resonance spectrum was measured, it showed a peak based on the carbon of an aromatic ring at delta of around 110 to 160 ppm, a peak based on the carbon of an alkene at delta of around 80 to 140 ppm, and a peak based on the carbon of an alkyl at delta of around 20 to 60 ppm. [0132] It was confirmed from the above results that the isolated product was a compound represented by the following formula (E1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Tokuyama Corporation; IZUMI, Shinobu; TERANISHI, Kazuhiro; DAIKOKU, Yusuke; SANDO, Mitsuyoshi; EP2725017; (2014); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2612-28-4, name is 2-Propylpropane-1,3-diol, the common compound, a new synthetic route is introduced below. Recommanded Product: 2-Propylpropane-1,3-diol

3rd Step 2-Propyl-1,3-propanediol 17.4 g (147 mol) and the above 3-(4-trifluoromethylphenyl)propanal 20.0 g (98.9 mmol) were dissolved in toluene 200 ml, and PTS 1 g was added, and the mixture was refluxed with heating for 3 hours while removing water formed with Dien-Stark. The reactant was washed with a saturated sodium bicarbonate aqueous solution, and then with saturated sodium chloride aqueous solution, and dried over anhydrous magnesium sulfate, and the solvent was distilled off. The residue was purified by silica gel column chromatography (eluent: toluene), and recrystallized twice from ethanol to obtain 5-propyl-2-(2-(4-trifluoromethylphenyl)ethyl)-1,3-dioxane 10.8 g (35.7 mmol). The yield was 36.1% from 3-(4-trifluoromethylphenyl) propanal. 1H-NMR(CDCl3) delta(ppm): 7.41 (dd,4H), 4.41(t,1H), 4.18-4.00(m,2H), 3.41-3.16(m,2H), 2.88-2.70(m,2H), 2.14-1.80(m,3H), 1.35-0.81(m,7H)

The synthetic route of 2612-28-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chisso Corporation; US6235355; (2001); B1;,
Alcohol – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 221285-25-2, name is (2-Amino-6-fluorophenyl)methanol. A new synthetic method of this compound is introduced below., Computed Properties of C7H8FNO

General procedure: A solution of 4-toluene sulfonyl chloride (4.58 g, 1.2 equiv) or methanesulfonyl chloride (1.9 mL, 1.2 equiv) and pyridine (2 mL, 1.3 equiv) in 20 mL CH2Cl2 was added slowly to the solution of compound 11 (0.02 mol) in 40 mL CH2Cl2. The mixture was stirred overnight at room temperature. Then 30 mL diluted HCl solution was added to the reaction mixture, the organic layer was separated using separating funnel. Subequently, the aqueous phase was extracted with 15 mL CH2Cl2 three times, the combined organic layers were washed separately with saturated NaHCO3 (30 mL) and saturated NaCl (30 mL) three times. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by column chromatography using petroleum ether/EtOAc = 1/1 to give the product 12.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 221285-25-2, (2-Amino-6-fluorophenyl)methanol.

Reference:
Article; Xu, Changrui; Wu, Zhengxing; Chen, Jianzhong; Xie, Fang; Zhang, Wanbin; Tetrahedron; vol. 73; 14; (2017); p. 1904 – 1910;,
Alcohol – Wikipedia,
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Reference of 558-42-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 558-42-9, name is 1-Chloro-2-methyl-2-propanol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1.Preparation of I-(6-amino-pyridin-3-yloxy)-2-methyl-propan-2-olTo a microwave flask containing 6-aminopyridin-3-ol hydrobromide (700 mg, 3.66 mmol) and 1-chloro-2-methyl-2-propanol (597 mg, 5.5 mmol) in anhydrous dimethylformamide (17 ml) was added cesium carbonate (3.7 g, 11.4 mmol) and the material was heated in a microwave oven at 140° C. for 3 hours.The vial was cooled to ambient and the solvent was concentrated in vacuo (rotary evaporator/mechanical pump).The residue was taken up in methylene chloride and filtered to remove insolubles, rinsing well with methylene chloride.The crude material was purified by HPLC on silica gel, eluting with a gradient of 2percent to 10percent methanol/methylene chloride to provide the desired product as a orange-brown viscous oil which solidified on standing (449 mg). MS (H+)=183 m/e.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 558-42-9, 1-Chloro-2-methyl-2-propanol.

Reference:
Patent; Berthel, Steven Joseph; Billedeau, Roland Joseph; Brotherton-Pleiss, Christine E.; Firooznia, Fariborz; Gabriel, Stephen Deems; Han, Xiaochun; Hilgenkamp, Ramona; Jaime-Figueroa, Saul; Kocer, Buelent; Lopez-Tapia, Francisco Javier; Lou, Yan; Orzechowski, Lucja; Owens, Timothy D.; Tan, Jenny; Wovkulich, Peter Michael; US2012/40949; (2012); A1;,
Alcohol – Wikipedia,
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Synthetic Route of 769-30-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 769-30-2, name is Benzo[d][1,3]dioxol-4-ylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

Example 6; Method AT5; Preparation of 1-Benzof1 3]dioxol-4-yl-2-bromo-ethanone; Step 1: Preparation of starting material 1-Benzor1, 3]dioxol-4-yl-ethanone; To a solution of MeMgBr in THF (1 M, 50 mL, 50 mmol, 1.5 eq) was diluted with 50 mL THF and cooled to-10 C. A solution of benzo [1,3] dioxole-4-carboxaldehyde (5.0 g, 33.3 mmol) in 50 mL THF was slowly added, and the reaction left to stir for 1 h. The reaction mixture was then quenched by pouring into 500 mL of ice cold sat. ammonium chloride and the mixture extracted with ether. The organic layers were dried over sodium sulfate and filtered through a plug of silica gel before concentrating in vacuo, providing 4.9 g of a white solid. A mixture of this solid (2.0 g, 12.0 mmol) and MnO2 (10.5 g, 120. 4 mmol, 10.0 eq) in 75 mL diethyl ether was stirred vigorously for 48 h. The reaction mixture was then filtered first through a plug of silica gel, then through a 0. 46 um frit before concentrating in vacuo to provide 2. 1g of an off-white solid. Purification by MPLC (Biotage) using a hexane-ethyl acetate gradient provided 1.47 g (74%) of 1- benzo [1,3] dioxol-4-yl-ethanone as an off-white solid. 1H-NMR (CDC13) 6 7.35 (d, J = 8 Hz, 1H), 6.97 (dm, J = 8 Hz, 1H), 6.87 (dd, J = 8 Hz, 1H), 6.08 (s, 2 H), 2.59 (s, 3H); TLC Rf = 0.18, 25% ethyl acetate-hexanes.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 769-30-2, Benzo[d][1,3]dioxol-4-ylmethanol.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2003/72561; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts