Tag: M.W=100-200

Application of 2612-28-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2612-28-4, name is 2-Propylpropane-1,3-diol, molecular formula is C6H14O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 5 A mixture of 1.2 g of 2-propylpropane-1,3-diol, 2.59 g of 5-(2-pentyl-5-pyridyl)-2-formyl-thiophene (obtainable by formylation of 5-(2-pentyl-5-pyridyl)-thiophene via a Vilsmeier reaction), 0.01 g of p-toluenesulfonic acid and 15 ml of toluene is boiled for 3 hours, using a water separator, cooled, washed with water and evaporated. 5-(2-Pentyl-5-pyridyl)-2-(trans-5-propyl-1,3-dioxan-2-yl)-thiophene is obtained.

According to the analysis of related databases, 2612-28-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Merck Patent Gesellschaft Mit Beschrankter Huftung; US4659503; (1987); A;,
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Electric Literature of 748805-85-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 748805-85-8 as follows.

General procedure: A solution of 4-toluene sulfonyl chloride (4.58 g, 1.2 equiv) or methanesulfonyl chloride (1.9 mL, 1.2 equiv) and pyridine (2 mL, 1.3 equiv) in 20 mL CH2Cl2 was added slowly to the solution of compound 11 (0.02 mol) in 40 mL CH2Cl2. The mixture was stirred overnight at room temperature. Then 30 mL diluted HCl solution was added to the reaction mixture, the organic layer was separated using separating funnel. Subequently, the aqueous phase was extracted with 15 mL CH2Cl2 three times, the combined organic layers were washed separately with saturated NaHCO3 (30 mL) and saturated NaCl (30 mL) three times. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by column chromatography using petroleum ether/EtOAc = 1/1 to give the product 12.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,748805-85-8, its application will become more common.

Reference:
Article; Xu, Changrui; Wu, Zhengxing; Chen, Jianzhong; Xie, Fang; Zhang, Wanbin; Tetrahedron; vol. 73; 14; (2017); p. 1904 – 1910;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 27871-49-4, name is (S)-Methyl 2-hydroxypropanoate. This compound has unique chemical properties. The synthetic route is as follows. Formula: C4H8O3

Under an Ar atmosphere, to a solution of methyl L-lactate (10.0 g, 96.1 mmol) in THF (100.0 mL) were added NEt3 (33.5 mL 240.2 mmol), DMAP (1.17 g, 9.6 mmol) and TBSCl (19.3 g, 128.1 mmol) at 0C, and the mixture was stirred for 24 h at r.t. The reaction mixture was diluted with Et2O, successively washed with 10% HCl aq. and sat. NaHCO3 aq., dried over MgSO4, filtered, and concentrated in vacuo. The resulting oil was purified by column chromatography on silica gel (hexane:AcOEt = 5:1) to afford the TBS ether (S-1) (20.9 g, 95.5 mmol, 99%) as a colorless oil.

With the rapid development of chemical substances, we look forward to future research findings about 27871-49-4.

Reference:
Article; Sugimoto, Kenji; Kobayashi, Yuta; Hori, Ayana; Kondo, Takashi; Toyooka, Naoki; Nemoto, Hideo; Matsuya, Yuji; Tetrahedron; vol. 67; 40; (2011); p. 7681 – 7685;,
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Reference of 5339-85-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5339-85-5, name is 2-(2-Aminophenyl)ethanol. A new synthetic method of this compound is introduced below.

General procedure: A test tube (25 mL) wascharged with 2-aminophenethyl alcohol 1? (0.5 mmol, 1 equiv), aldehyde 2?? (0.75mmol, 1.5 equiv), AgOTf (0.025 mmol, 5 mol%), HOTf (0.05 mmol, 10 mol%), and toluene (3 mL) were added. Themixture was stirred at 120 oC in air for 12 hours, thereaction was cooled down to room temperature, the mixture was quenched by sat.aq. NaHCO3, and diluted with 10 mL dichloromethane and washed with10 mL H2O. The aqueous layer was extracted twice withdichloromethane (10 mL) and the combined organic phase was dried over Na2SO4.After evaporation of the solvents, the residue was purified by silica gelchromatography (hexane/AcOEt = 30:1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5339-85-5, 2-(2-Aminophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Article; Xu, Xuefeng; Zhang, Xu; Liu, Wenming; Zhao, Qiang; Wang, Zhiqiang; Yu, Lintao; Shi, Fu; Tetrahedron Letters; vol. 56; 24; (2015); p. 3790 – 3792;,
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Related Products of 3840-31-1 ,Some common heterocyclic compound, 3840-31-1, molecular formula is C10H14O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a 25-mL Schlenk tube equipped with a magnetic stirrer, CuCl (0.05 mol, 5 mol%), DABCO (0.10 mol, 10 mol%), 4-HO-TEMPO (0.05 mmol, 5 mol%) were added. Substrates 1 (1 mmol) and NH3 (aq, 25-28%, 3 mmol, 3.0 equiv) in CH3CN (2 mL) were added subsequently. Then the reaction mixture was stirred at room temperature for 24 h in the presence of an air balloon. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous MgSO4. Subsequently, the combined organic layer was concentrated under reduced pressure and the crude product was purified by column chromatography to afford the corresponding products.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3840-31-1, (3,4,5-Trimethoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Hu, Yongke; Chen, Lei; Li, Bindong; Chinese Chemical Letters; vol. 29; 3; (2018); p. 464 – 466;,
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Application of 1562-00-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1562-00-1, name is Sodium isethionate, molecular formula is C2H5NaO4S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Reaction product V, [C1impd]2[SO4] (3.166 g, 8.74 mmol) was dissolved in 2:1 alcohol-water (30 mL), whereupon a prepared solution of sodium isethionate (2.592 g, 17.50 mmol) in 2:1 alcohol-water (18 mL) was added to it with stirring. The resulting slurry was stirred for about 2 h, whereupon it was suction filtered, and the filtrate was concentrated as far as feasible by rotary evaporation. The residue was taken up in methanol (25 mL) and loaded onto an about 12-g column of 230-400 mesh silica gel previously packed in methanol.As in Example 3, the methanolic solution of crude [C1impd][ise] was pushed down to the level of the top of the silica gel bed with air pressure while the column issue was collected in a 250-mL round bottom flask; the flask previously containing the crude product was rinsed with methanol (25 mL) and the rinse methanol was similarly loaded and pressed down while the column issue was collected on top of the first fraction. The rinsing process was repeated once before the silica gel column was washed down with fresh methanol (125 mL), all the while collecting the column issue on top of the accumulated methanol solution. The combined methanolic fractions were concentrated by rotary evaporation to produce purified [C1impd][ise] (4.122 g, 15.96 mmol, 91%) as an ionic liquid. The ionic liquid of Example 11 slowly solidified at ambient conditions. Specifically, it was freely liquid when contained in a flask immersed in an 80 C. water bath; it remained liquid for several hours after it was removed from the water bath. Thereafter, several regions of the liquid began to slowly solidify independently of each other, and after about 1 day, the IL had turned thoroughly solid under ambient conditions.

According to the analysis of related databases, 1562-00-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FLUIDIC, INC.; US2012/321967; (2012); A1;,
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Electric Literature of 6351-10-6 , The common heterocyclic compound, 6351-10-6, name is 2,3-Dihydro-1H-inden-1-ol, molecular formula is C9H10O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

DMAP (143.8 mg, 1.25 mol) and acetic anhydride (1185.6 L,12.48 mmol) were added to a rac-indanol (rac-2), 500 mg,4.16 mmol) solution in dichloromethane (40 mL). The reaction wasstirred at room temperature during 4 h and after that time, thesolvent was evaporated under reduced pressure. The resultingcrude was purified by flash chromatography on silica gel (5-95%EtOAc/hexane) to afford the desired rac-indanyl acetate (rac-3) asa yellow liquid in 80% yield.

The synthetic route of 6351-10-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; De Mattos, Marcos Carlos; De Fonseca, Thiago Sousa; Da Silva, Marcos Reinaldo; De Oliveira, Maria Da Conceicao Ferreira; De Lemos, Telma Leda Gomes; De Marques, Ricardo Araujo; Applied Catalysis A: General; vol. 492; 1; (2015); p. 76 – 82;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3637-61-4, name is Cyclopentanemethanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Cyclopentanemethanol

Synthesis of methyl 3- (4-CYCLOPENTYLMETHYLOXYPHENYL) propionate (Intermediate 2); A solution of cyclopentane methanol (4.05 ml, Ald) in anhydrous tetrahydrofuran (abbreviated as”THF”hereinafter, 40 ml) was added with triethylamine (6.49 ml, WAKO), added dropwise with methanesulfonyl chloride (3.48 ml, WAKO) under ice cooling, and stirred for 30 minutes. The reaction mixture was added with water (50 ml), and extracted with diethyl ether (80 ml X 2). The organic layer was washed with saturated brine and dried, and then the solvent was evaporated under reduced pressure. A solution obtained beforehand by adding 60% sodium hydride (1.15 g, KANTO) to a solution of Intermediate 1 (4.50 g) in N, N-dimethylformamide (abbreviated as”DMF”hereinafter, 35 ml) under ice cooling and stirring the solution for 15 minutes was added with a solution of the aforementioned residue in DMF (10 ml) under ice cooling. The reaction mixture was stirred for 15 minutes, then warmed to room temperature, stirred for 45 minutes, and further stirred at 60C for 15 hours. The reaction mixture was added with water (100 ML) and diethyl ether (200 ml) for extraction. The organic layer was successively washed with saturated aqueous sodium hydrogencarbonate, saturated aqueous ammonium chloride, and saturated brine and dried, and then the solvent was evaporated under reduced pressure. The residue was purified by flash column chromatography (hexane : isopropyl ether = 9: 1) to obtain the title compound (Intermediate 2,5. 58 G).

With the rapid development of chemical substances, we look forward to future research findings about 3637-61-4.

Reference:
Patent; ASAHI KASEI PHARMA CORPORATION; WO2005/16862; (2005); A1;,
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Synthetic Route of 6301-54-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 6301-54-8 as follows.

General procedure: In a round bottom ask tted with three-way cock with septumwas placed benzyl alcohol analogue (1.0e1.5 mmol). The ask waslled with nitrogen after reducing pressure. After slight decom-pression to ease to the gas introduction, HI gas (0.5e2.0 equiv.) wasbrought in the vessel with syringe through the septum (the weightof HI gas was calculated the change of the weight of the equipmentbefore and after the introduction of HI gas). And nitrogen gas wasintroduced into vessel to release deference of pressure against at-mosphere. The mixture stood at 25C for 2 d. After reducingpressure to release HI gas, to the reaction mixture was addedsaturated Na2S2O3 (20 mL) and brine (15 mL). After being extractedwith CHCl3 or Et2O (15 mL 3), the organic layer was dried withMgSO4. After the concentration, ca. 10.0 mg of the residue wascombined with p-chlorobenzaldehyde (ca. 10.0 mg) as an internalstandard. And the mixture was measured with1H NMR to deter-mine the yield by the integration of methyl, methylene or methinepeak of the product and formyl peak of p-chlorobenzaldehyde(9.98 ppm). Furthermore, the reaction mixture included in p-chlorobenzaldehyde was subject to column chromatography onSiO2 to give the product.Iodinated products, (iodomethyl)benzene (2a),29(1-iodoethyl)benzene (2b),30and reduction products, diphenylmethane (3d),311,1-diphenylethane (3e),32triphenylmethane (3f),33wereassigned by the corresponding proton peaks at benzylic positionscompared with the chemical shift reported in the literature.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6301-54-8, its application will become more common.

Reference:
Article; Matsumoto, Shoji; Naito, Masafumi; Oseki, Takehisa; Akazome, Motohiro; Otani, Yasuhiko; Tetrahedron; vol. 73; 52; (2017); p. 7254 – 7259;,
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Electric Literature of 100-37-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-37-8, name is 2-(Diethylamino)ethanol, molecular formula is C6H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

diethylaminoethyl methacrylate is synthesized by using diethylaminoethanol and methyl methacrylate as raw materials and lithium hydroxide as a catalyst. The process steps are as follows:(1) Synthesis: 300 g (3.0 mol) of methyl methacrylate, 117 g (1.0 mol) of diethylaminoethanol, 10 g of lithium hydroxide and 0.6 g of hydroquinone were added to a 1000 mL with stirring, a thermometer and a vacuum fractionation apparatus. The three-necked flask was heated to 75 C to 85 C, and the temperature at the top of the column was controlled to be 50 C to 55 C. The methanol was continuously separated under a negative pressure of about 600 mmHg, and the reaction was stopped until no methanol was separated (about 3.5 h). Methanol 33.0 g was separated, and gas chromatographic analysis showed that the methanol content was 89.3% and the methyl methacrylate content was 9.6%.(2) Purification: Cool to room temperature and wash twice with 300 mL × 2 of deionized water. The oil phase is gradually depressurized (40-100 mmHg), and unreacted methyl methacrylate and diethylaminoethanol are distilled off at 70 C to 100 C, and then distilled under reduced pressure at 5 to 10 mmHg and 90 C to 100 C. Diethylaminoethyl acrylate. The weight of the obtained mixture of methyl methacrylate and diethylaminoethanol was 195.8 g, and gas chromatographic analysis showed that the methyl methacrylate content was 95.9% and the diethylaminoethanol content was 3.6%. This mixture can be used directly for the synthesis of diethylaminoethyl methacrylate. The weight of the obtained product was 174.1 g (theoretical yield: 185.26 g), and the yield was 94.0%. The gas chromatographic analysis showed that the content of diethylaminoethyl methacrylate was 99.4%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 100-37-8, 2-(Diethylamino)ethanol.

Reference:
Patent; Sinopec Corporation; Sinopec Corporation Victory Oil Field Fen Corporation Petroleum Engineering Technology Institute; Zhang Songting; Yang Shengli; Bai Xin; Rong Yan; Du Chunan; Chen Xiaochun; Cai Qingjun; Ma Tiantai; Sun Lizhu; Yue Jiwen; (10 pag.)CN108976136; (2018); A;,
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