Tag: M.W=100-200

Synthetic Route of 63478-76-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63478-76-2, name is 6-Heptyn-1-ol, molecular formula is C7H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 6-heptynol (331 mg, 2.95 mmol) in 10 ml of methanol was added KOH in 5 ml of H2O. After 10 min, iodine (824 mg, 3.24 mmol) was added at 0 C. and warmed to rt and stirred for 2 hr. The reaction was then quenched with water and extracted with ether (20 ml three times). The solvent was removed in vacuo, the residue dissolved in CH2Cl2, washed with brine and dried over MgSO4. Purification by silica gel chromatography (hexane:ethyl acetate=4:1) gave the product 498 mg (71% yield).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 63478-76-2, 6-Heptyn-1-ol.

Reference:
Patent; Iowa State University Research Foundation, Inc.; US2005/272954; (2005); A1;,
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Reference of 28539-02-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.28539-02-8, name is 1-(Hydroxymethyl)benzotriazole, molecular formula is C7H7N3O, molecular weight is 149.15, as common compound, the synthetic route is as follows.

Preparation Example 144 To a mixture of 5-(piperidin-4-yl)-1,3-thiazol-2-amine hydrochloride (519 mg), dichloromethane (5 mL), and methanol (5 mL), 1H-benzotriazol-1-ylmethanol (423 mg), sodium acetate (388 mg), and sodium triacetoxy borohydride (1.0 g) in that order were added followed by stirring at room temperature for 2 hours. To the reaction mixture, a saturated aqueous sodium hydrogen carbonate solution and basic silica gel were added followed by concentration of the solvent under reduced pressure. The resulting residue was purified by basic silica gel column chromatography (chloroform/methanol) to give 5-(1-methylpiperidin-4-yl)-1,3-thiazol-2-amine (411 mg).

The chemical industry reduces the impact on the environment during synthesis 28539-02-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; KOTOBUKI PHARMACEUTICAL CO., LTD.; Astellas Pharma Inc.; Kameda, Minoru; Kuriwaki, Ikumi; Iikubo, Kazuhiko; Hisamichi, Hiroyuki; Kawamoto, Yuichiro; Moritomo, Hiroyuki; Suzuki, Tomoyuki; Futami, Takashi; Suzuki, Atsushi; Tsunoyama, Kazuhisa; Asaumi, Makoto; Tomiyama, Hiroshi; Noda, Atsushi; Iwai, Yoshinori; Tokuzaki, Kazuo; Okada, Haruki; Miyasaka, Kozo; US2014/142084; (2014); A1;,
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Synthetic Route of 2240-88-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2240-88-2, name is 3,3,3-Trifluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Step 3; Preparation of tert-butyl 2-cvclopropyl-4-(3,3,3-trifluoropropoxy)-5,6,8,9- tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate; [057] 3,3,3-Trifluoropropan-1-ol (0.43 g, 3.7 mmol) was dissolved in 1 ,4-dioxane (5 mL). Potassium tert-butoxide (572 mg, 5.1 mmol) was added, and the mixture was stirred at rt for 15 min. tert-Butyl 4-chloro-2-cyclopropyl-5,6,8,9-tetrahydro-7H-pyrimido[4,5- EPO d]azepine-7-carboxylate (1.1 g, 3.4 mmol) was then added as a solution in 1 ,4-dioxane (5 ml_). The mixture was heated at 50°C overnight. The resulting white suspension was concentrated under reduced pressure, and the residue was partitioned between water and ethyl acetate. The organic layer was separated, dried (MgSO4), and concentrated under reduced pressure to give the title compound as a colorless oil (1.2 g, 94percent).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2240-88-2, 3,3,3-Trifluoropropan-1-ol.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2006/44762; (2006); A2;,
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Application of 5187-23-5, Adding some certain compound to certain chemical reactions, such as: 5187-23-5, name is (5-Ethyl-1,3-dioxan-5-yl)methanol,molecular formula is C7H14O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5187-23-5.

Example 12: Synthesis of Tetradecafluoro-di(propylamino)- phthalocyaninatocobalt(II), Dodecafluoro-tetrapyrrolidino-phthalocyaninatocobalt(II) and MONO- (5-ETHYL-1, 3-DIOXANE-5-METHYLOXY)-HEXAFLUORO-TETRANEOPENTOXY-PENTAPYRROLIDIYAO- phthalocyaninatocobalt (II) [00129] FI6COPC (40 mg) was dissolved in 1 ml of propylamine and stirred for 10 min. Then the amine was evaporated and an aliquot was taken for MALDI-MS. It shows substitution of 1-6 fluorines by propylamine. To the remaining solid 1 ml of pyrrolidine was added and the suspension was stirred at room temperature for 5 min. After that the pyrrolidine was evaporated and an aliquot was taken for MALDI-MS. It shows substitution of 3-4 fluorines by pyrrolidine but no more products with propylamine as the substituent. To the remaining solid 1 ml of diisopropylamine was added and the mixture was heated to 80C for 4 hrs. The amine was evaporated and an aliquot taken for MALDI-MS. It shows substitution of 3-5 fluorines by pyrrolidine. There is no evidence that diisopropylamine has reacted with the Pc. To the remaining solid (dark blue green) was added a mixture of 0.93 ml nBuLi and 328 mg neopentylalcohol. The mixture was stirred at 110C for 90 min. Since the suspension almost solidified, some 5-ethyl-1, 3-dioxane-5-methanol was added and heated to 140C for 1 h. The colour turned from green to brown. But after cooling down it was green again. So another 328 mg neopentylalcohol were added and heated to 140C for 90 min. The colour turned brown again. The mixture was purified by silica gel chromatography with ethylacetate/hexanes (1: 1) as the eluent. An olive green and a green fraction were taken and submitted for MALDI-MS. Two peaks among several could be identified: [00130] 1) fluorines were replaced by 5 pyrrolidines and 4 neopentylalcohols [00131] 2) the same as above with an 5-ethyl-1, 3-dioxane-5-methanoxy. [00132] The reaction schemes for the synthesis of the various products of this example are provided in Figure 7.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5187-23-5, (5-Ethyl-1,3-dioxan-5-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; YORK UNIVERSITY; WO2005/33110; (2005); A1;,
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Reference of 7218-43-1 ,Some common heterocyclic compound, 7218-43-1, molecular formula is C7H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

120mg NaH (60%) was added to a solution of 144mg 1-propargyl diethylene glycol in 5mL THF,Stir at room temperature for 15 minutes, then add 152 mg of bromoacetic acid and heat to reflux for 6 hours.After the reaction was completed, 10 mL of saturated ammonium chloride solution was added to quench the reaction, and the organic phase was separated.The aqueous phase was extracted three times with dichloromethane and incorporated into the organic phase,It was washed successively with saturated aqueous ammonium chloride solution and saturated brine, and then dried over anhydrous sodium sulfate,The sodium sulfate was removed by filtration and concentrated to obtain the crude product.The crude product was isolated by column chromatography (200-300 mesh silica gel, eluent dichloromethane: methanol = 50: 1) to obtain pure intermediate 26.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7218-43-1, 2-[2-(2-Propynyloxy)ethoxy]ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ShanghaiTech University; Tao Houchao; Zhao Fei; (85 pag.)CN110894209; (2020); A;,
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Adding a certain compound to certain chemical reactions, such as: 702-82-9, 3-Aminoadamantan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 3-Aminoadamantan-1-ol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 3-Aminoadamantan-1-ol

General procedure: N-Ethyl-N’-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDCI) (0.15 g, 0.78 m Mol, 1.2 equiv) and 3-amino-5,7-dimethyladamantan-1-ol (9b) (0.15 g, 0.76 m Mol, 1.06 equiv) were successively added to a solution of 2-(3-oxobenzo[d]isothiazol-2(3H)-yl)acetic acid (8) (0.15 g, 0.72 m Mol, 1.0 equiv) in anhydrous DMF (5 mL) at ambient temperature. The resulting reaction mixture was stirred at ambient temperature for 70 h. The solvent was evaporated under reduced pressure and the residue was partitioned between water (20 mL) and ethyl acetate (10 mL). The aqueous phase was additionally extracted with ethyl acetate (3 * 7 mL). The combined organic layer was successively washed with 5% aqueous solution of citric acid (7 mL), 5% aqueous solution of NaHCO3 (8 mL), brine (10 mL), dried over anhydrous Na2SO4, filtered and evaporated under reduced pressure. Crystallization of the crude product from a mixture consisting from ethyl acetate and hexanes provided 1c (47 mg, 17%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,702-82-9, 3-Aminoadamantan-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Zhulenkovs, Dmitrijs; Rudevica, Zhanna; Jaudzems, Kristaps; Turks, Maris; Leonchiks, Ainars; Bioorganic and Medicinal Chemistry; vol. 22; 21; (2014); p. 5988 – 6003;,
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Related Products of 37585-25-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37585-25-4, name is (2-Amino-5-chlorophenyl)methanol, molecular formula is C7H8ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of 2-amino-5-chlorophenylmethanol (11.1g, 70.4mmol) in tetrahydrofuran (50mL) was added imidazole (5.27g, 77.5mmol), followed by careful addition of terf-butyldimethylchlorosilane (10.62g, 70.4mmol). The reaction mixture was stirred for 24 hours. Imidazole (528mg, 7.75mmol) and tert-butyldimethylchlorosilane (1.06g, 7.03mmol) were then added. After 1 hour the solid was filtered off and washed with diethyl ether (2 x 20ml_) and the filtrate was washed with water (10mL), brine (10ml_), dried over magnesium sulfate and concentrated in vacuo to give the product as a brown oil, 18.83g (98%).1H NMR (400 MHz, CDCI3): 5 0.07 (6H, s), 0.90 (9H, s), 4.63 (2H, s), 6.60 (1H, d), 7.01 (1H, d), 7.05 (1H, m); LRMS: m/z APCI+272[MH+].

According to the analysis of related databases, 37585-25-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2006/21882; (2006); A1;,
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Synthetic Route of 111-46-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.111-46-6, name is 2,2′-Oxybis(ethan-1-ol), molecular formula is C4H10O3, molecular weight is 106.1204, as common compound, the synthetic route is as follows.

A mixture of 2- (2-methoxyethoxy) ethanol(2A) (21.2 g, 0.2 mol) andCesium carbonate (8.55 g, 0.05 mol) was dissolved in N, N-dimethylformamide (50 mL), Benzyl bromide (27.7 g, 0.085 mol) was added and stirred at room temperature for 3 daysThe The reaction solution was added with water (300 mL) and extracted with ethyl acetate (100 mL x 2)The combined organic phases were washed with saturated brine, dried over anhydrous sodium sulfate,The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography(Petroleum ether / ethyl acetate (v / v) = 1: 0 to 5: 1) to give the title product2- (2-benzyloxyethoxy) ethanol (2B) as a pale yellow oil(4.0 g, yield 40%).

The chemical industry reduces the impact on the environment during synthesis 111-46-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; Wei, Yonggang; Qiu, Guanpeng; Lu, Yonghua; Zhu, Guozhi; (40 pag.)TW2017/8238; (2017); A;,
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Adding a certain compound to certain chemical reactions, such as: 617-94-7, 2-Phenyl-2-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C9H12O, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C9H12O

General procedure: In a round-bottom flask, benzylic alcohol 1a (10 mmol, 2.0 equiv.), benzenesulfonyl chloride 2a (13 mmol, 1.3 equiv.) and NMP (2.5 equiv.). Then, DCE (3 mL) were added. The mixture was stirred at 80 C for 1.5 h. After completion of the reaction (monitoredby TLC), water (10 mL) was added and the mixture was extracted with ethyl acetate (3*10 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and evaporated under reduced pressure. The crude product was purified by flash chromatography on silica gel to give the desired alkyl chlorides 3.

The synthetic route of 617-94-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zheng, Dagui; Mao, Liu-Liang; Zhu, Xian-Hong; Zhou, An-Xi; Synthetic Communications; vol. 48; 21; (2018); p. 2793 – 2800;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6240-11-5, name is 1-Adamantaneethanol. A new synthetic method of this compound is introduced below., Formula: C12H20O

EXAMPLE 1 Methyl-1-(2-(1-adamantyl)ethyl)-5-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylate. A solution of 11.8 mL trifluoromethanesulfonic anhydride in 70 mL dichloromethane is chilled to -70 C. and treated dropwise with a solution composed of 12.6 g 1-adamantyl-2-hydroxyethane, 12.2 mL diisopropylethylamine and 70 mL dichloromethane. The solution is allowed to warm to -55 C. over 45 min then a solution of 25 g N,1-bis-BOC-histidine methyl ester (J. Chem. Soc., Perkin Trans. I 1982; 1553-61.) in 70 mL dichloromethane is added dropwise. The reaction is then stirred at 25 C. for 24 hr and poured into pH=7, 0.25M potassium phosphate buffer (500 mL), stirring vigorously. The organic layer is separated, washed with the same buffer, dried and concentrated. 3-(2-(1-Adamantyl)ethyl)-N-BOC-histidine methyl ester is isolated by chromatography on silica gel (chloroform-methanol, 99:1) as a gum. NMR (CDCl3) 3.85 (m,2H,NCH2).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6240-11-5, 1-Adamantaneethanol.

Reference:
Patent; Warner-Lambert Company; US4812462; (1989); A;,
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