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Related Products of 1227159-85-4 ,Some common heterocyclic compound, 1227159-85-4, molecular formula is C11H13BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 2: 1-Bromo-4-[1-(methoxymethyl)cyclobutyl]benzene 1.28 g (31.9 mmol) of a 60% strength suspension of sodium hydride in mineral oil were added to a solution of 7.0 g (29.0 mmol) of the compound from Example 110A/step 1 in 120 ml of anhydrous DMF at approx. 5 C. After the mixture had been stirred at this temperature for 1 h, 2.2 ml (34.8 mmol) of methyl iodide were added. The reaction mixture was allowed to warm to RT and stirring was continued for 15 h. The reaction mixture was then concentrated to a volume of approx. 20 ml on a rotary evaporator. Approx. 500 ml of water were added and the mixture was extracted three times with approx. 200 ml of diethyl ether each time. The combined organic extracts were washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After filtration and removal of the solvent on a rotary evaporator, the crude product obtained was purified by means of filtration with suction over approx. 200 g of silica gel with cyclohexane/ethyl acetate 50:1 as the mobile phase. 4.92 g (66% of th.) of the title compound were obtained. 1H-NMR (400 MHz, CDCl3, delta/ppm): 7.41 (d, 2H), 7.04 (d, 2H), 3.48 (s, 2H), 3.27 (s, 3H), 2.32-2.22 (m, 4H), 2.12-2.00 (m, 1H), 1.90-1.80 (m, 1H). MS (DCI, NH3): m/z=272/274 [M+NH4]+. GC/MS (method L, ESIpos): Rt=5.25 min, m/z=254/256 [M]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1227159-85-4, its application will become more common.

Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; Haerter, Michael; Beck, Hartmut; Ellinghaus, Peter; Berhoerster, Kerstin; Greschat, Susanne; Thierauch, Karl-Heinz; Suessmeier, Frank; US2013/196964; (2013); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5339-85-5, name is 2-(2-Aminophenyl)ethanol, molecular formula is C8H11NO, molecular weight is 137.18, as common compound, the synthetic route is as follows.Quality Control of 2-(2-Aminophenyl)ethanol

A 250 mL 3 -neck round-bottom flask equipped with mechanical stirrer and a temperature -probe was set up under N2. Ethyl acetetate (45 mL) and 2-aminophenethanol (2.0 g, 0.015 mol, purchased from Combi- Blocks Inc, San Diego, CA) were added and stirred well in a ice bath cooled to 0 to 5 C. A homogeneous clear solution of K2C03 in water (45 mL) was added in one portion. To a vigorously stirring solution was added acryloyl chloride (0.7 g, 0.007 mol, Sigma Aldrich) carefully in portions with a syringe at a rate that maintains the temperature below 5oC. To the resulting solution was added BHT (0.004 g, 0.018 mmol). After 4 hours, reaction progress was monitored by silica gel TLC (50:50 DCM:EtOAc eluent). Product: f=~0.5 (UV-active). The starting material was not observed. The reaction mixture then was diluted with ethyl acetate (100 mL), transferred to a separatory funnel, and washed with IN HCI (50 mL), sat. aq. NaHC03 (50 mL.), brine (50 mL), dried (Na2S04), filtered, and concentrated on a rotovap to obtain a white solid that was further dried under high, vacuum. 1H NMR (400 MHz, Acetone-d6). d (ppm) 9.64 (br, IH), 7.93 (d, 1H), 7.20 (m, 2H), 7.02 (dd, IH), 6.33 (m, 2H), 5.70 (d, IH), 4.71 (s, 1 H), 3.86 (dd, 2H), 2.86 (dd, 2H). This product was used without further purification in the next step of sy nthesis.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5339-85-5, 2-(2-Aminophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; SNAP BIO, INC.; BURK, Mark J.; CHEN, Brandon; LI, Jingyi; BACHAN, Shawn; (161 pag.)WO2019/67396; (2019); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6240-11-5, name is 1-Adamantaneethanol, molecular formula is C12H20O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 6240-11-5

General procedure: To a three-necked, cylindrical Pyrex glass reaction vessel equipped with a rubber balloon, rubberseptum, and glass stopper, a N2 atmosphere was introduced by flowing via cannula for 5 min. Au(0.6 wt %)/TiO2 (117.3 mg, 0.17 mol % Au), 1a (271.5 mg, 1.99 mmol), and dehydrated ethylacetate (25 mL) were added successively to the vessel. After N2 gas was reintroduced more than 5min, the rubber balloon was connected to the vessel and the mixture was sonicated. The vessel wasimmersed in a oil bath (kept at 45 oC) and stirred for 10 h under irradiation (lambda = 300-470 nm). 1HNMR analysis of this crude mixture using mesitylene as an internal standard indicated 97%conversion of 1a and the formation of 2a in 86% yield, as determined based on the signals at delta 3.61ppm and 2.94 ppm (shifted from 2.89 ppm due to the presence of ethyl acetate), respectively. Theproduct was purified by silica gel column chromatography (n-hexane/ethyl acetate 3:1) to afford 2a(180 mg, 66% yield, with inclusion of small amounts of unidentified impurities).

With the rapid development of chemical substances, we look forward to future research findings about 6240-11-5.

Reference:
Article; Shibata, Masaki; Nagata, Ryoko; Saito, Susumu; Naka, Hiroshi; Chemistry Letters; vol. 46; 4; (2017); p. 580 – 582;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3597-91-9, name is [1,1′-Biphenyl]-4-ylmethanol, the common compound, a new synthetic route is introduced below. Quality Control of [1,1′-Biphenyl]-4-ylmethanol

In a 10 mL round bottom flask, 0.85 g of 4-hydroxymethylbiphenyl (4-phenylbenzyl alcohol) and 2 g of diethylene glycol dimethyl ether were sequentially added, and the resulting mixture was subjected to an ultrasonic reaction apparatus at 40 KHz/30 W/70. C Ultrasonic radiation was allowed to open for 35 minutes. The diethylene glycol dimethyl ether was removed under reduced pressure, and recrystallized to give 0.95 g of 4-phenylbenzoic acid, yield 96%.

The synthetic route of 3597-91-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Central South University; Xiao Fang; Xiao Yuanyuan; Zeng Ming; Li Na; Yin Lirong; (15 pag.)CN108467342; (2018); A;,
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Application of 106-28-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.106-28-5, name is (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol, molecular formula is C15H26O, molecular weight is 222.37, as common compound, the synthetic route is as follows.

To a stirred mixture of (E,E)-farnesol 1 (0.50 g, 2.25 mmol) in non-dried DCM (50 mL) under nitrogen was added Dess-Martin periodinane (1.43 g, 3.40 mmol), and the resulting mixture stirred for 2 h 50 min. Saturated aqueous sodium bicarbonate solution (20 mL) was added dropwise, the mixture stirred 10 min, then extracted with DCM (3 x 25 mL). The organic layer was dried (MgSO4), and the solvent was removed in vacuo. The crude product was purified using flash chromatography (19:1 hexanes: ethyl acetate) to give the title product (0.495 g, 99%) as a clear colourless oil.

Statistics shows that 106-28-5 is playing an increasingly important role. we look forward to future research findings about (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-ol.

Reference:
Article; Duhamel, Nina; Martin, Damian; Larcher, Roberto; Fedrizzi, Bruno; Barker, David; Tetrahedron Letters; vol. 57; 40; (2016); p. 4496 – 4499;,
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Electric Literature of 100751-63-1, Adding some certain compound to certain chemical reactions, such as: 100751-63-1, name is 6-Bromo-2-naphthylmethanol,molecular formula is C11H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 100751-63-1.

To a solution of (6-bromonaphtbalen-2-yl)methanol (0.7 g, 2.97 mmol) in dichloromethane (20mL) was added TBSCI (667 mg, 4.45 mmol) and imidazole (302 mg, 4.45 mmol). After theaddition, the reaction mixture was stirred at 25 C for 1 h. The reaction was then quenched by addition of saturated aqueous NI-l4Cl (20 mE) and extracted with ethyl acetate (3 x 30 mL). The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by silica-gel chromatography (petroleum ether: ethyl acetate = 30: 1) togive the title compound (0.8 g, 77 % yield) as a colorless oil.

According to the analysis of related databases, 100751-63-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; GEHLING, Victor; HSIAO-WEI TSUI, Vickie; KIEFER, James, Richard, Jr.; LIANG, Jun; MAGNUSON, Steven; NASVESCHUK, Christopher, G.; PASTOR, Richard; ROMERO, F. Anthony; TAYLOR, Alexander, M.; ZHANG, Birong; (287 pag.)WO2016/112284; (2016); A1;,
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Reference of 1454-85-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1454-85-9, name is Heptadecan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

To an ice-cold solution of heptadecanol (2.0 g, 7.8 mmole) in methylenechloride (20 rut) and TEA (3 rat, 20 rumole) was added the abovesuspension of acid chloride (9.3 mmole) in nethylene chloride (20 mL). After stirring for 10 ninutes at ice bath tenperature, the ice?bath was removed and stirring continued at room temperature for 4 h. The reaction mixture was then washed with water (2 x 8 mL) followed bybrine (10 mL), dried over anhydrous sodium sulfate, filtered and concentrated. The crude residue was purified by column chromatography using 5percent methanol in methylene chloride to give the pure required compound 17 (1.1 g, 27percent) as a off white solid, m.p.llo?112¡ã C. ?H NHR (CDC13) 5 0.87 (t, d, .1=7.2 Hz, 3H), 1.24 (m, 28H), 1.40?1.51 (m, 4H),1.60?1.79 (m, 2H), 2.55 (s,3H), 2.75 (m, 3H), 2.85?3.06 (m, 4H),3.60?3.85 (m,3H), 4.03(t, d, J=7.2 Hz, 2H), 4.88 (m,1H), 4.94(m,lH); ESMS:507 (H+H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1454-85-9, Heptadecan-1-ol.

Reference:
Patent; LIXTE BIOTECHNOLOGY, INC.; KOVACH, John, S.; JOHNSON, Francis; SAMUDRALA, Ramakrishna; GUPTA, Ramesh, C.; WO2015/73802; (2015); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.37585-25-4, name is (2-Amino-5-chlorophenyl)methanol, molecular formula is C7H8ClNO, molecular weight is 157.6, as common compound, the synthetic route is as follows.Application In Synthesis of (2-Amino-5-chlorophenyl)methanol

To 40 ml of DMS0 in the reactor, PdCl2 (dppf), organic ligand L1, potassium carbonate and an auxiliary agent, And 12 mmol of the compound of formula (I) and 18 mmol of the compound of formula (II) in the above reaction scheme, with nitrogen being inert to formAtmosphere, sealed reaction at 110 C for 5 hours, the reaction is completed by natural cooling, vacuum concentration, the use of petroleum ether and ethyl acetate(1: 2 by volume) as the eluent to give the compound of the above formula (III) in a yield of96.7%;[0053] wherein the molar amount of the PdCl2 (dppf) is 1.2% by mol of the compound of the formula (I), and the ligand LlIs used in an amount of 3% by mol based on the molar amount of the compound of formula (I), the molar amount of said potassium carbonate being a molar amount of the compound of formula (I)35% and the molar amount of said auxiliary PhSiH3 is 1.5% by mol based on the compound of formula (I).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,37585-25-4, (2-Amino-5-chlorophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Wang, Wenming; (10 pag.)CN104557737; (2016); B;,
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Adding a certain compound to certain chemical reactions, such as: 552331-15-4, 1-(5-Bromo-2-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 552331-15-4, blongs to alcohols-buliding-blocks compound. COA of Formula: C8H8BrFO

To a stirred solution of 1 -(5 -bromo-2-fluorophenyl)ethanol 30-1 (1.2 g, 5.48 mmol) in DCM (15 ml) was added tribromophosphine (0.26 mL, 2.74 mmol). The reaction mixture was stirred at 0C for lh, and then diluted with DCM (50 mL). Then saturated NaHCO3 solution was added dropwise to the mixture, and the layers were separated. The organic layer was washed with saturated NaHCO3 solution (3OmL), brine (30 mL), and then dried over Na2SO4, and concentrated to give the crude product 30-2, which was used in the next step without purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,552331-15-4, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; HAGMANN, William K.; NARGUND, Ravi P.; BLIZZARD, Timothy A.; JOSIEN, Hubert; BIJU, Purakkattle; PLUMMER, Christopher W.; DANG, Qun; LI, Bing; LIN, Linus S.; CUI, Mingxiang; HU, Bin; HAO, Jinlai; CHEN, Zhengxia; WO2014/19186; (2014); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.33420-52-9, name is 2,2-Difluoropropan-1-ol, molecular formula is C3H6F2O, molecular weight is 96.076, as common compound, the synthetic route is as follows.Product Details of 33420-52-9

Trifluoromethanesulfonic anhydride (9.34 mL, 55.2 mmol) was added to a solution of 2,2-difluoropropan-1-ol (5.05 g, 52.6 mmol) in DCM (100 mL) at -10 C followed by dropwiseaddition of 2,6-dimethylpyridine (7.35 mL, 63.1 mmol) in DCM (50 mL). The reaction was stirred for 1 hour before addition of 2N HC1 (150 mL). The layers were separated and the aqueous phase was extracted with DCM (100 mL), then the combined organics were dried and concentrated carefully (no lower than 200 mbar, 40 C) to afford 2,2-difluoropropyltrifluoromethanesulfonate (12.90 g) as a brownlred oil that was used directly in next stage.2,2-Difluoropropyl trifluoromethanesulfonate (11.91 g, 52.22 mmol) was added to a solution of (R)-1-(1H-indol-3-yl)propan-2-amine (6.50 g, 37.3 mmol) and DIPEA (12.9 ml, 74.6 mmol) in 1 ,4-dioxane (75 mL) and the reaction was then heated to 65 C for 1.5 hours. The reaction was cooled to room temperature and diluted with EtOAc (250 mL). This waswashed with water (2 x 100 mL) and saturated aqueous sodium chloride (100 mL). The organic phase was separated and dried (MgSO4), filtered and evaporated. The crude product was purified by flash silica chromatography, elution gradient 0 to 10% MeOH in DCM to afford (R)-N-( 1 -(1 H-indol-3 -yl)propan-2-yl)-2,2-difluoropropan- 1-amine (7.99 g, 85%) as an orange/brown oil. ?H NMR (500 MHz, CDC13, 27 C) 1.11 (3H, d), 1.58 (3H, t), 2.77 -3.00 (4H, m), 3.07 (1H, h), 7.04 (1H, d), 7.12 (1H, ddd), 7.19 (1H, ddd), 7.36 (1H, dt), 7.57- 7.62 (1H, m), 8.03 (1H, s). (One proton not observed). m/z: ES+ [M+H]+ 253.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,33420-52-9, 2,2-Difluoropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; SCOTT, James, Stewart; MOSS, Thomas, Andrew; YANG, Bin; VARNES, Jeffrey, Gilbert; O’DONOVAN, Daniel, Hillebrand; NISSINK, Johannes, Wilhelmus, Maria; HUGHES, Samantha, Jayne; BARLAAM, Bernard, Christophe; WU, Dedong; BROO, Dan, Anders; (224 pag.)WO2018/19793; (2018); A1;,
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